Results 231 to 240 of about 19,776 (295)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Association of Sperm DNA Fragmentation and Intracytoplasmic Sperm Injection Outcomes in an Age-adjusted Cohort: A Retrospective Cohort Study. [PDF]

J Hum Reprod Sci
Shah N, Talwar D, Modi D, Rathore S, Chandra V, Murdia K, Murdia N.   +6 more
europepmc   +1 more source

Age‐Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age

Aging Cell, Volume 25, Issue 7, July 2026.
Decidual macrophages (DM) in advanced maternal age (AMA) exhibit FOXO3 deficiency‐driven senescence, further accelerated by elevated uterine IL‐6. This manifests as pro‐inflammatory polarization, increased senescence markers, reduced phagocytosis, and impaired trophoblast function.
Yujing Zhang, Yiming Zhang, Guangshun Gong, Zhijing Li, Wenjing Xiong, Xuhui Fang, Ning Lu, Di Wang, Yihui Li, Aihua Liao   +9 more
wiley   +1 more source

Personalized prediction model for miscarriage: in-depth sperm DNA fragmentation. [PDF]

J Assist Reprod Genet
Lee CI, Wang TE, Chen CH, Huang CC, Tsao HM, Lee TH, Chang TA, Hsu CT, Lee MS.   +8 more
europepmc   +1 more source

Pig Seminal Plasma Extracellular Vesicles Enhance Motility During Preservation of Epididymal Spermatozoa but Impair Capacitation and IVF Parameters

Andrology, Volume 14, Issue 5, Page 1249-1260, July 2026.
ABSTRACT Background Extracellular vesicles (EVs) produced by accessory sex glands play a key role in sperm functionality, influencing motility, viability, acrosome integrity, metabolic activity, and capacitation. Most studies on the effects of EVs on spermatozoa have focused on ejaculated spermatozoa, which have already been exposed to their own native
Ana Moya‐Fernández, Santa María Toledo‐Guardiola, Peter Silke, Sergio Navarro‐Serna, Carmen Matás   +4 more
wiley   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, Volume 14, Issue 5, Page 1089-1101, July 2026.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Induction of Sperm DNA Fragmentation by Cryopreservation and In Vitro Incubation: Comparison of TUNEL, SCSA, SCD Test and COMET Assay. [PDF]

Int J Mol Sci
Calamai C, Tanturli M, Conti D, Leter G, Vignozzi L, Giovannelli L, Muratori M.   +6 more
europepmc   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, Volume 14, Issue 5, Page 1272-1281, July 2026.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

Sperm DNA Fragmentation Impairs Early Embryo Development but Is Not Predictive of Pregnancy Outcomes: Insights from 870 ICSI Cycles. [PDF]

Int J Mol Sci
Machałowski T, Machałowska J, Gill K, Ziętek M, Piasecka M, Mrugacz G, Ciepiela P.   +6 more
europepmc   +1 more source