Results 81 to 90 of about 19,776 (295)

Study Protocol: Comparison of Clinical Pregnancy Outcomes of Intracytoplasmic Sperm Injection (ICSI) Using Testicular and Ejaculated Spermatozoa in Male Patients with High DNA Fragmentation

Journal of Pharmacy and Bioallied Sciences
Background: This study aims to compare the clinical pregnancy outcome of intracytoplasmic sperm injection (ICSI) using testicular and ejaculated spermatozoa in male patients with high deoxyribonucleic acid (DNA) fragmentation.
Juhi Barai, Akash More, Namrata Choudhary   +2 more
doaj   +1 more source

Effect of sperm DNA fragmentation on ICSI outcome: A prospective study [PDF]

, 2020
Aim and objectives: The primary aim was to measure the sperm DNA damage and to study the magnitude of sperm DNA damage. Secondary objective was to study the effect of sperm DNA fragmentation on Day 5 Blastocyst expansion (graded 1-5).
Harish Ramya, Sharma Nidhi*, Saravanan Mahalakshmi, Saravanan Lakshamanan   +3 more
core   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Can Altered Expression of HSPA2 in Varicocele Patients Lead to Abnormal Spermatogenesis? [PDF]

International Journal of Fertility and Sterility, 2010
Background Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function. Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis.
Mohammad Hossein Nasr Esfahani, Homayoun Abbasi, Zahra Mirhosseini, Nazem Ghasemi, Shahnaz Razavi, Marziyeh Tavalaee, Somayeh Tanhaei, Mohammad Reza Deemeh, Kamran Ghaedi, Farzaneh Zamansoltani, Farzad Rajaei   +10 more
doaj   +1 more source

Future direction in sperm DNA fragmentation testing [PDF]

Translational Andrology and Urology, 2017
Dr. Rey, in his commentary (1), has provided us with a comprehensive summary of the practice recommendations proposed by Agarwal et al . (2) with additional discussion on the basic physiology of sperm DNA structure.
Cho, Chak-Lam, Agarwal, Ashok, Majzoub, Ahmad, Esteves, Sandro C.   +3 more
openaire   +2 more sources

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation

Basic and Clinical Andrology, 2023
Background Spermatogenesis and sperm quality may be negatively impacted by an increase in reactive oxygen species. This study investigates the efficacy of combined antioxidant therapy for treating male infertility, as measured by semen analyses and the ...
Nguyen Dac Nguyen, Minh Tam Le, Nhu Quynh Thi Tran, Quoc Huy Vu Nguyen, Thanh Ngoc Cao   +4 more
doaj   +1 more source

REPRODUCTION AND SPERM DNA FRAGMENTATION

Bulletin of Problems Biology and Medicine, 2019
The aim of this work was to search and analyze literature data about sperm DNA fragmentation and its role in reproduction. There are reports that men of couples with infertility have more sperm with DNA damage. If the number of sperm DNA damage exceeds 25-30% the probability of in vivo fertilization and intrauterine insemination is estimated to be ...
Kaleinikova O. M., Sribna V. O., Vinogradova-Anyk - O. O., Voznesenskaya T. Y., Blashkiv T. V.   +4 more
openaire   +2 more sources