Results 61 to 70 of about 16,246 (249)

Study Protocol: Comparison of Clinical Pregnancy Outcomes of Intracytoplasmic Sperm Injection (ICSI) Using Testicular and Ejaculated Spermatozoa in Male Patients with High DNA Fragmentation

Journal of Pharmacy and Bioallied Sciences
Background: This study aims to compare the clinical pregnancy outcome of intracytoplasmic sperm injection (ICSI) using testicular and ejaculated spermatozoa in male patients with high deoxyribonucleic acid (DNA) fragmentation.
Juhi Barai, Akash More, Namrata Choudhary   +2 more
doaj   +1 more source

REPRODUCTION AND SPERM DNA FRAGMENTATION

Bulletin of Problems Biology and Medicine, 2019
The aim of this work was to search and analyze literature data about sperm DNA fragmentation and its role in reproduction. There are reports that men of couples with infertility have more sperm with DNA damage. If the number of sperm DNA damage exceeds 25-30% the probability of in vivo fertilization and intrauterine insemination is estimated to be ...
Kaleinikova O. M., Sribna V. O., Vinogradova-Anyk - O. O., Voznesenskaya T. Y., Blashkiv T. V.   +4 more
openaire   +2 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Can Altered Expression of HSPA2 in Varicocele Patients Lead to Abnormal Spermatogenesis? [PDF]

International Journal of Fertility and Sterility, 2010
Background Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function. Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis.
Mohammad Hossein Nasr Esfahani, Homayoun Abbasi, Zahra Mirhosseini, Nazem Ghasemi, Shahnaz Razavi, Marziyeh Tavalaee, Somayeh Tanhaei, Mohammad Reza Deemeh, Kamran Ghaedi, Farzaneh Zamansoltani, Farzad Rajaei   +10 more
doaj   +1 more source

Sperm DNA fragmentation: laboratory and clinical aspects [PDF]

Translational Andrology and Urology, 2017
The commentary by Drs. Khalili and Agha-Rahimi on the sperm DNA fragmentation (SDF) clinical guideline article by Agarwal et al . (1) recognized the presence of a negative association between high seminal SDF levels and fertility outcome specifically with assisted reproductive techniques (ART).
Majzoub, Ahmad, Agarwal, Ashok, Esteves, Sandro C.   +2 more
openaire   +2 more sources

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation

Basic and Clinical Andrology, 2023
Background Spermatogenesis and sperm quality may be negatively impacted by an increase in reactive oxygen species. This study investigates the efficacy of combined antioxidant therapy for treating male infertility, as measured by semen analyses and the ...
Nguyen Dac Nguyen, Minh Tam Le, Nhu Quynh Thi Tran, Quoc Huy Vu Nguyen, Thanh Ngoc Cao   +4 more
doaj   +1 more source

A guide to sperm DNA fragmentation testing [PDF]

Translational Andrology and Urology, 2017
A conundrum exists in the field of male infertility as in many other areas of medical study. It is described by the adage that advises one to not order a test or exam if you don’t know what to do with the results. The urologists’ conundrum is: how to use the information we have learned about abnormalities in sperm chromatin, specifically DNA ...
Lynne, Charles M., Brackett, Nancy L.
openaire   +2 more sources

Sperm DNA fragmentation assay by sperm chromatin dispersion (SCD): correlation between DNA fragmentation and outcome of intracytoplasmic sperm injection [PDF]

Reproductive Medicine and Biology, 2013
AbstractPurposeThe aim of the present study was to investigate the relationship between sperm DNA fragmentation index (sDFI) and outcome of intracytoplasmic sperm injection (ICSI).MethodsAll the patients were divided into two groups based on sperm DNA fragmentation analysis by the sperm chromatin dispersion (SCD) method. A total of 237 patients were in
T, Sivanarayana, Ch, Ravi Krishna, G, Jaya Prakash, K M, Krishna, K, Madan, G, Sudhakar, G A, Rama Raju   +6 more
openaire   +2 more sources

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source