Results 51 to 60 of about 31,775 (244)

Spermatids as gametes: indications and limitations [PDF]

Human Reproduction, 1998
The feasibility of achieving viable embryos, developing to term after transfer into the uterus, by fertilizing oocytes with spermatids has been demonstrated both in animal studies and in preliminary human clinical trials. Here we review the current clinical indications of spermatid conception and discuss the predictable success rates associated with ...
J, Tesarik, M, Sousa, E, Greco, C, Mendoza   +3 more
openaire   +2 more sources

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Generation of Haploid Spermatids with Fertilization and Development Capacity from Human Spermatogonial Stem Cells of Cryptorchid Patients

Stem Cell Reports, 2014
Generation of functional spermatids from azoospermia patients is of unusual significance in the treatment of male infertility. Here, we report an efficient approach to obtain human functional spermatids from cryptorchid patients.
Shi Yang, Ping Ping, Meng Ma, Peng Li, Ruhui Tian, Hao Yang, Yang Liu, Yuehua Gong, Zhenzhen Zhang, Zheng Li, Zuping He   +10 more
doaj   +1 more source

Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesis. [PDF]

PLoS Genetics, 2017
Spermatogenesis is a dynamic developmental process requiring precisely timed transitions between discrete stages. Specifically, the germline undergoes three transitions: from mitotic spermatogonia to spermatocytes, from meiotic spermatocytes to ...
Michael John Fairchild, Fayeza Islam, Guy Tanentzapf   +2 more
doaj   +1 more source

Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis [PDF]

, 1990
Expression of the Lactate Dehydrogenase (LDH) genes during various stages of spermatogenesis was studied by using a combination of Northern blot analyses and in situ hybridization techniques.
Bellvé, Anthony, Del Mazo, Jesus, Eversole, Pam, Hiraoka, Yukihiro, Li, Steven S. L., Simon, Melvin, Thomas, Kelwyn   +6 more
core  

Analysis of the transcriptional program governing meiosis and gametogenesis in yeast and mammals [PDF]

, 2006
During meiosis a competent diploid cell replicates its DNA once and then undergoes two consecutive divisions followed by haploid gamete differentiation.
Schlecht, Ulrich
core   +1 more source

Clinical efficacy of spermatid conception: analysis using a new spermatid classification scheme [PDF]

Human Reproduction, 1999
Fertilization and pregnancy outcomes of 50 round spermatid injection (ROSI) and 20 elongated spermatid injection (ELSI) treatment cycles are related to various characteristics of the cycles, with particular reference to spermatid developmental stage as assessed by using a classification scheme adapted to this purpose.
M, Sousa, A, Barros, K, Takahashi, C, Oliveira, J, Silva, J, Tesarik   +5 more
openaire   +2 more sources

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source

Distinct roles of two myosins in C. elegans spermatid differentiation.

PLoS Biology, 2019
During spermatogenesis, interconnected haploid spermatids segregate undesired cellular contents into residual bodies (RBs) before detaching from RBs. It is unclear how this differentiation process is controlled to produce individual spermatids or motile ...
Junyan Hu, Shiya Cheng, Haibin Wang, Xin Li, Sun Liu, Mengmeng Wu, Yubing Liu, Xiaochen Wang   +7 more
doaj   +1 more source

The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids

BMC Genomics, 2010
Background The ubiquitin-conjugating enzyme HR6B is required for spermatogenesis in mouse. Loss of HR6B results in aberrant histone modification patterns on the trancriptionally silenced X and Y chromosomes (XY body) and on centromeric chromatin in ...
van IJcken Wilfred FJ, Sun Zu-Wen, Ooms Marja, Sleddens-Linkels Esther, Hoogerbrugge Jos W, Wassenaar Evelyne, Mulugeta Achame Eskeatnaf, Grootegoed J Anton, Baarends Willy M   +8 more
doaj   +1 more source