Results 31 to 40 of about 11,282 (214)
Cells, 2023 Using the nematode C. elegans germline as a model system, we previously reported that PUF-8 (a PUF RNA-binding protein) and LIP-1 (a dual-specificity phosphatase) repress sperm fate at 20 °C and the dedifferentiation of spermatocytes into mitotic cells ...
Youngyong Park +5 more
doaj +1 more source
Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility
Asian Journal of Andrology, 2015 The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo +3 more
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New insights into the regulation of cholesterol efflux from the sperm membrane
Asian Journal of Andrology, 2015 Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
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eLife, 2021 The male germ cells must adopt the correct morphology at each differentiation stage for proper spermatogenesis. The spermatogonia regulates its differentiation state by its own migration. The male germ cells differentiate and mature with the formation of
Yuki Osawa +20 more
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Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis
BioTechniques, 2011 A thorough understanding of the events during mammalian spermatogenesis requires studying specific molecular signatures of individual testicular cell populations as well as their interaction in co-cultures.
Yao-Fu Chang +4 more
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Biobanking efforts and new advances in male fertility preservation for rare and endangered species
Asian Journal of Andrology, 2015 Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
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Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
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The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly
Advanced Science, EarlyView.Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie +20 more
wiley +1 more source
Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage. [PDF]
PLoS Genetics, 2015 Onset of terminal differentiation in adult stem cell lineages is commonly marked by robust activation of new transcriptional programs required to make the appropriate differentiated cell type(s).
Chenggang Lu, Margaret T Fuller
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