Results 91 to 100 of about 26,767 (249)

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation

Biology Open, 2017
Male germ cell differentiation proceeds to a large extent in the absence of active gene transcription. In Drosophila, hundreds of genes whose proteins are required during post-meiotic spermatid differentiation (spermiogenesis) are transcribed in primary ...
Ina Theofel, Marek Bartkuhn, Thomas Boettger, Stefanie M. K. Gärtner, Judith Kreher, Alexander Brehm, Christina Rathke   +6 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Micromanipulation of Chromosomes in Insect Spermatocytes

Journal of Visualized Experiments, 2018
The micromanipulation of chromosomes has been an essential method for illuminating the mechanism for chromosome congression, the spindle checkpoint, and anaphase chromosome movements, and has been key to understanding what controls chromosome movements during a cell division. A skilled biologist can use a micromanipulator to detach chromosomes from the
Nicolas K H, Lin, Ryder, Nance, Jane, Szybist, Alan, Cheville, Leocadia V, Paliulis   +4 more
openaire   +3 more sources

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Centriole Migration in Primary Spermatocytes

, 2013
(A) Time-lapse series of confocal images from a wild-type primary spermatocyte expressing GFP-PACT (centrioles) and His2AvD–GFP (chromosomes). The centrioles (arrows) can be seen moving away from the plasma membrane (0) towards the nucleus (N) and then ...
Cayetano Gonzalez (10), Salud Llamazares (8), José Reina (9), Elena Rebollo (7)   +3 more
core   +1 more source

Seasonal evaluation of spermatogenesis of the hematophagous bat Desmodus rotundus in the Caatinga biome.

PLoS ONE, 2020
This study was aimed to characterize the spermatogenic process and its seasonal variation in Desmodus rotundus, in the Caatinga biome, a water-limited ecosystem, with marked water restriction during most of the year.
Soraia F M Silva, Laryssa C A Oliveira, Fernanda C R Dias, Eugenia Cordero-Schmidt, Juan C Vargas-Mena, Ingrid G M Silva, Sônia N Báo, João L S Luna, Ruthnaldo R M Lima, Raimundo F A Júnior, Naisandra B S Farias, Carlos E B Moura, Sérgio L P Matta, Danielle B Morais   +13 more
doaj   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

DMRTB1 is highly expressed specifically in first-wave spermatocytes from juvenile mice.

, 2019
Spermatocyte marker SYCP3 (red) and DMRTB1 (green) were stained in 5μm testis tissue sections from mice ages PND13, PND22, and adult. DMRTB1 protein is expressed in the nucleus of first-wave spermatocytes at PND13, with decreasing expression in pachytene
Yang Hu (315392), Jennifer K. Grenier (3595322), Andrew Grimson (3470567), Eileen Shu (6490865), Olivier Elemento (7617), Kathryn J. Grive (221479), Paula E. Cohen (218889)   +6 more
core   +1 more source