Results 81 to 90 of about 26,767 (249)

Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes

Toxics
Triptolide (TP) is a diterpenoid compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii. It has antitumor and anti-inflammatory effects and stimulates immunity.
Jiantao Zhao, Maosheng Cao, Haisheng Yi, Guitian He, Tong Chen, Lingyun Liu, Kaimin Guo, Yin Cao, Chunjin Li, Xu Zhou, Boqi Zhang, Hongliang Wang   +11 more
doaj   +1 more source

Synergistic Toxicity of Low‐Concentration Metal Mixture on Male Rats: Reproductive, Renal, and Hepatic Effects

Environmental Toxicology, EarlyView.
ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida, Thalita Tofanin Sargiani D'Assumpção, Ana Priscila Gomes Silva, Carolina Rocha Moreira de Oliveira, Tailisi Hoppe Trevizani, Rubens Cesar Lopes Figueira, Lucas Buruaem Moreira, Juliana Elaine Perobelli   +7 more
wiley   +1 more source

White guava (Psidium guajava L.) fruit juice ameliorated the number of spermatogenic cells in rats (Rattus Novergicus) exposed to lead acetate

Ovozoa: Journal of Animal Reproduction
This study aims to determine the effect of oral administration of white guava fruit juice (Psidium guajava L.) on the spermatogenic cells of rats (Rattus norvegicus) exposed orally to lead acetate.
Muhammad Faizal Adiutomo, Suzanita Utama, Herry Agoes Hermadi, Wurlina Wurlina, Hardany Primarizky, Rochmah Kurnijasanti   +5 more
doaj   +1 more source

Cytogenotoxic and Molecular Assessment of Pyrethrins on Non‐Target Allium cepa Roots

Environmental Toxicology, EarlyView.
ABSTRACT The pyrethrins, which form a part of naturally occurring insecticidal chemicals derived from chrysanthemum flowers, not only provide rapid knockdown of a broad spectrum of insect pests but are also widely used in integrated pest management due to a generally favorable safety profile, largely attributed to low mammalian toxicity.
Yudum Yeltekin Uğur, Rahsan Ilikci‐Sagkan, Recep Liman   +2 more
wiley   +1 more source

Arf-null pachytene spermatocytes exhibit synaptic defects.

, 2013
(A–C) Staining of surface spread spermatocytes for SYCP3 marks the lateral elements of bivalents. (A) In wildtype pachytene spermatocytes, fully synapsed autosomal bivalents are observed, as judged by continuous SYCP3 staining along the axes.
Scott Keeney (47164), Michelle L. Churchman (347537), Charles J. Sherr (347540), Ignasi Roig (47161), Maria Jasin (47165)   +4 more
core   +1 more source

Activation of the mitogen-activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes [PDF]

, 1998
Okadaic acid (OA) causes meiotic progression and chromosome condensation in cultured pachytene spermatocytes and an increase in maturation promoting factor (cyclin B1/cdc2 kinase) activity, as evaluated by H1 phosphorylative activity in anti-cyclin B1 ...
Geremia, R, Sette, C, Rossi, P, ROSSI, PELLEGRINO, Conti, M, SETTE, CLAUDIO, GEREMIA, RAFFAELE, Barchi, M, Bianchini, A, BARCHI, MARCO   +9 more
core   +1 more source

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.

PLoS Genetics, 2018
Three waves of H2AX phosphorylation (γH2AX) have been observed in male meiotic prophase I: the first is ATM-dependent and occurs at leptonema, while the second and third are ATR-dependent, occuring at zygonema and pachynema, respectively.
Hanwei Jiang, Qian Gao, Wei Zheng, Shi Yin, Liu Wang, Liangwen Zhong, Asim Ali, Teka Khan, Qiaomei Hao, Hui Fang, Xiaoling Sun, Peng Xu, Tej K Pandita, Xiaohua Jiang, Qinghua Shi   +14 more
doaj   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

E2-deficient spermatocytes have unrepaired DSBs that are increased by depletion of E1.

, 2014
Chromosome spreads from adult WT (a–d), E1+/+E2−/− (e–h), E1+/ΔE2−/− (i–l) and E1Δ/ΔE2−/− spermatocytes (m–o) immunostained for γH2AX (red) and SYCP3 (green). Insets represent the area outlined. (a–d) γH2AX pattern in WT prophase I.
Marcia Manterola (260674), Sanny S. W. Chung (528327), Peter Sicinski (528329), Debra J. Wolgemuth (124823), Laetitia Martinerie (332874), Sunil K. Panigrahi (124819), Ana Vasileva (18008), Yan Geng (268097), Melissa Weisbach (528328)   +8 more
core   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source