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Sulphasalazine and Spermatogenesis

Digestion, 2009
The semen of 11 patients with inflammatory bowel disease treated with sulphasalazine (Salazopyrin) was analysed and compared with that of 6 men with similar disease not treated with the drug. The treated group had significantly reduced sperm population density and motility compared with the untreated group.
J G, Freeman, V A, Reece, C W, Venables
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Spermatogenesis

2012
During spermatogenesis, pluripotent germ cells differentiate to become efficient delivery vehicles to the oocyte of paternal DNA. Though male and female germ cells both undergo meiosis to produce haploid complements of DNA, at the same time they also each undergo distinct differentiation processes that result in either sperm or oocytes.
Diana S, Chu, Diane C, Shakes
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Spermatogenesis in fish

General and Comparative Endocrinology, 2010
Spermatogenesis is a developmental process during which a small number of diploid spermatogonial stem cells produce a large number of highly differentiated spermatozoa carrying a haploid, recombined genome. We characterise morphologically the different germ cell stages with particular attention for the spermatogonial generations, including the stem ...
Rüdiger W, Schulz   +7 more
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Spermatogenesis in the dog

The Anatomical Record, 1972
AbstractThe cycle of the seminiferous epithelium of the dog was divided into eight stages, using as criteria the shape of the spermatid nucleus, the location of spermatids and spermatozoa in regard to the basement membrane, the presence of meiotic figures and the release of spermatozoa from the lumen of the tubule.
R H, Foote, E E, Swierstra, W L, Hunt
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Epigenetics in spermatogenesis

Molecular and Cellular Endocrinology, 2009
DNA methylation is a heritable epigenetic modification of cytosine residues within CpG dinucleotides associated with the modulation of gene expression and found at 20-30 million sites throughout the mammalian genome. The methylation of DNA is catalyzed by DNA (cytosine-5)-methyltransferases (DNMTs), regulates genes during development and plays a role ...
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MicroRNAs and spermatogenesis

Fertility and Sterility, 2014
In mammals, male gametes are produced inside the testis by spermatogenesis, which has three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid differentiation of spermatids. The genome of male germ cells is actively transcribed to produce phase-specific gene expression patterns.
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Spermatogenesis in Drosophila

The International Journal of Developmental Biology, 1996
A short summary on the present knowledge on spermatogenesis in Drosophila is given which also points out particular questions of interest in the context of this morphogenetic process. Such points of interest are the formation of lampbrush loops in primary spermatocytes, the chromosomal events during meiosis, the occurrence of chromatin rearrangements ...
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Testosterone and spermatogenesis

Journal of Endocrinology, 1987
Abstract In mammals spermatogenesis is totally dependent upon testosterone. It is produced by the Leydig cells and acts upon the Sertoli and peritubular cells of the seminiferous tubule and, via processes which are virtually unknown, drives spermatogenesis (Sharpe, 1986).
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Hypoxia and spermatogenesis

International Urology and Nephrology, 2013
This review mainly focuses on our understanding of spermatogenesis in physiological and pathological hypoxic condition. Real hypoxia is closely related to vascular changes and an increase in testicular temperature. Both induce a reduction in sperm count and can be related to the increase in germ cell apoptosis.
Ljubinka, Jankovic Velickovic   +1 more
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Microtubules and spermatogenesis

Seminars in Cell & Developmental Biology, 2014
Microtubules are dynamic polymers of tubulin subunits that underpin many essential cellular processes, such as cell division and migration. Spermatogenesis is the process by which spermatogenic stem cells undergo mitotic and meiotic division and differentiation to produce streamlined spermatozoa capable of motility and fertilization.
O'Donnell, L., O'Bryan, M.
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