ASRGL1 is highly expressed specifically in spermatogonia from neonatal and juvenile mice.
, 2019 Spermatogonial marker PLZF (red) and ASRGL1 (green) were stained in 5μm testis tissue sections from mice ages PND7, PND13, PND22, and adult. DAPI (blue) denotes nuclei. ASRGL1 protein expression decreases in PLZF+ spermatogonia with age.
Yang Hu (315392) +6 more
core +1 more source
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis
Andrology, Volume 14, Issue 7, Page 2329-2346, October 2026.ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan +10 more
wiley +1 more source
Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances
Andrology, Volume 14, Issue 7, Page 1962-1970, October 2026.ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang +4 more
wiley +1 more source
Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines
Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede +11 more
wiley +1 more source
A proteomic and phosphoproteomic comparison of mouse spermatogonial stem cells and progenitor spermatogonia [PDF]
David Anthony Skerrett-Byrne +12 more
openalex +1 more source
A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance
Cell Proliferation, Volume 59, Issue 10, October 2026.SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu +11 more
wiley +1 more source
PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation [PDF]
Zhaokai Yao +15 more
openalex +1 more source
Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids [PDF]
Tsung-Yen Lin +10 more
openalex +1 more source
Restoration of spermatogenesis is dependent on activation of a SPRY4-ERK checkpoint following germline stem cell damage†. [PDF]
Biol ReprodLiu Y +10 more
europepmc +1 more source