Results 91 to 100 of about 1,019 (188)

Hidradenitis suppurativa with and without draining tunnels: A real‐world study characterizing differences in treatment and disease burden

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 8, Page 1431-1441, August 2025.
This real‐world study found that patients with moderate–severe hidradenitis suppurativa (HS) and draining tunnels experienced a greater clinical and health‐related quality of life burden compared with patients without draining tunnels. This study indicates that more effective treatments are needed for patients with moderate–severe HS with draining ...
J. R. Ingram, A. V. Marzano, E. Prens, S. Schneider‐Burrus, R. B. Warren, A. Keal, R. Jha, A. C. Hernandez Daly, A. B. Kimball   +8 more
wiley   +1 more source

Improvement of acute phase symptoms of pemphigus foliaceus with spesolimab

JAAD Case Reports
Shohei Iida, MD, PhD, Ken Muramatsu, MD, PhD, Ayaka Mizuno, MD, Akinobu Hayashi, MD, PhD, Yuki Mizutani, MD, PhD, Hideyuki Ujiie, MD, PhD, Kazumitsu Sugiura, MD, PhD, Keiichi Yamanaka, MD, PhD   +7 more
doaj   +2 more sources

Pneumocystis pneumonia in a patient with severe generalized pustular psoriasis treated with biologics [PDF]

First published: 31 October 2023journal ...
Akiyama, Masashi, Hayai, Shunsaku, Muro, Yoshinao, Noguchi, Haruka, Takeichi, Takuya, Yoshikawa, Masato   +5 more
core   +1 more source

Evolution of Eligibility Criteria in Inflammatory Bowel Disease Clinical Trials: A Clinical Trial Databank Analysis

United European Gastroenterology Journal, Volume 13, Issue 4, Page 542-551, May 2025.
ABSTRACT Background Eligibility criteria in clinical trials have been criticised for being overly restrictive without clinical justification. Objective We aimed to investigate the types, evolution, and current status of eligibility criteria in clinical trials for inflammatory bowel diseases (IBD).
An Outtier, Rosanne Janssens, Liese Barbier, João Sabino, Bram Verstockt, Séverine Vermeire, Isabelle Huys, Marc Ferrante   +7 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 899-941, May 2025.
HS treatment algorithm. Abstract Introduction This second part of the S2k guidelines is an update of the 2015 S1 European guidelines. Objective These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS ...
C. C. Zouboulis, F. G. Bechara, F. Benhadou, V. Bettoli, Z. Bukvić Mokos, V. Del Marmol, M. Dolenc‐Voljč, E. J. Giamarellos‐Bourboulis, Ø. Grimstad, P. Guillem, B. Horváth, R. E. Hunger, J. R. Ingram, D. Ioannidis, E. Just, L. Kemény, B. Kirby, A. I. Liakou, B. M. McGrath, A. V. Marzano, Ł. Matusiak, A. Molina‐Leyva, A. Nassif, M. Podda, E. P. Prens, F. Prignano, H. Raynal, M. Romanelli, D. M. L. Saunte, A. Szegedi, J. C. Szepietowski, T. Tzellos, S. Valiukevičienė, H. H. van der Zee, K. R. van Straalen, B. Villumsen, G. B. E. Jemec   +36 more
wiley   +1 more source

Investigating Mechanisms of Immune Function and New Therapeutic Targets in Rare Autoimmune Diseases [PDF]

Autoimmune diseases affect approximately 5-8% of the population worldwide and are characterized by defective or misdirected immune responses. Studies have shown that most autoimmune diseases result from a complex interplay of several factors, including ...
Hecker, Julia
core   +1 more source

Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease

The Journal of Dermatology, Volume 52, Issue 3, Page 400-407, March 2025.
Abstract Generalized pustular psoriasis (GPP) is a severe autoinflammatory keratinization disease (AiKD) characterized by acute flares of widespread sterile pustules and high fever. GPP is potentially life‐threatening. Recently clarified genetic predisposing factors for GPP suggest that the excessive activation of innate immune pathways in the skin ...
Masashi Akiyama
wiley   +1 more source

Efficacy and safety of spesolimab in the treatment of Generalized Pustular Psoriasis: a systematic review. [PDF]

A psoríase pustulosa generalizada (PPG) é uma doença rara e potencialmente fatal, caracterizada por uma erupção generalizada de pústulas estéreis. O spesolimab é um novo anticorpo monoclonal que tem como alvo o recetor IL36RN, sendo dirigido para o ...
Cristiana Maria Louzada de Almeida
core  

Spesolimab treatment for the prevention of flares in people with generalized pustular psoriasis (GPP): a plain language summary of the Effisayil ™ 2 study [PDF]

What is this study about?: Generalized pustular psoriasis (shortened to GPP) is a rare, potentially life-threatening disease in which pus-filled blisters or pustules may suddenly form all over the body.
Anadkat, Milan J, Burden, A. David, Choon, Siew Eng, Gordon, Kenneth B, Haeufel, Thomas, Hu, Na, Lebwohl, Mark G, Marrakchi, Slaheddine, Morita, Akimichi, Strober, Bruce, Thaçi, Diamant, Thoma, Christian, Tsai, Tsen-Fang, Zheng, Min   +13 more
core   +1 more source

Pustules in a 59‐year‐old Hispanic man

JEADV Clinical Practice, Volume 4, Issue 2, Page 616-620, June 2025.
Judith M. Corona‐Herrera, Betzabé Quiles‐Martínez, Fanny C. López‐Jiménez, Rebeca Palafox‐Romo, Saeb‐Lima Marcela, Salazar H. Amparo, Silvia Méndez‐Flores   +6 more
wiley   +1 more source