Results 71 to 80 of about 787 (175)

Aseptic meningitis due to intravenous immunoglobulin therapy (IVIG) in therapy‐refractory pyoderma gangraenosum

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katharina A. Kälber, Knut Schäkel, Alexander Enk, Julia K. Winkler   +3 more
wiley   +1 more source

Palmoplantar pustulosis: pathogenesis, differential diagnosis, and treatment

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 516-535, April 2026.
Summary Palmoplantar pustulosis (PPP) is a chronic inflammatory and often painful disease characterized by sterile pustules on the palms and soles, significantly impairing quality of life. Women are more frequently affected than men, and smoking is a major trigger. Under biologic therapies, especially TNF antagonists, a paradoxical PPP may occur.
Rotraut Mössner, Tanja Fetter, Robert Sabat, Ulrich Mrowietz, Neda Cramer, Dagmar Wilsmann‐Theis   +5 more
wiley   +1 more source

Case Report: Successful treatment of generalized pustular psoriasis with concomitant renal insufficiency using spesolimab: a report of two cases

Frontiers in Immunology
Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening neutrophilic dermatosis. Management focuses on rapid control of acute flares and prevention of recurrence.
You Xie, You Xie, You Xie, Feng Cheng, Feng Cheng, Feng Cheng, Zilu Qu, Zilu Qu, Zilu Qu, Lei Hu, Lei Hu, Lei Hu, Yun Xia, Yun Xia, Yun Xia, Liuqing Chen, Liuqing Chen, Liuqing Chen, Jinbo Chen, Jinbo Chen, Jinbo Chen   +20 more
doaj   +1 more source

Severe generalized pustular psoriasis complicated with staphylococcal toxic shock syndrome treated with spesolimab and antibiotics

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Spyridon Gkalpakiotis, Jan Hugo, Natalie Michalik, Robert Zajicek, Cecilie Stonova, Bohumil Bakalar   +5 more
wiley   +1 more source

Systemic single‐cell analysis of GPP reveals treatment‐responsive and persistent immune signatures

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Soyoung Jeong, Seungbok Lee, Christine Suh‐Yun Joh, James G. Krueger, Hyun Je Kim, Seong Jin Jo, Jong‐Hee Chae   +6 more
wiley   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, Volume 268, Issue 3, Page 249-262, March 2026.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Exploring the Quality-of-Life Impact, Disease Burden, and Management Challenges of GPP: The Provider and Patient Perspective [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Jason E Hawkes,1,* Dale V Reisner,2 Tina Bhutani3,* 1Department of Dermatology, University of California at Davis, Sacramento, CA, USA; 2Patient Author, Yankton, SD, USA; 3Psoriasis and Skin Treatment Center, Department of Dermatology, University
Hawkes JE, Reisner DV, Bhutani T
doaj  

Bilateral Idiopathic Pyoderma Gangrenosum: A Case Report of an Atypical Presentation

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Pyoderma gangrenosum (PG) is a rare non‐infectious neutrophilic dermatosis which is characterized by a rapidly progressive, painful ulcer. Bilateral manifestation of PG is exceptionally rare and can easily be misdiagnosed as infection or vascular ulceration, delaying proper treatment.
Sanjog Thapa Magar, Deekshanta Sitaula, Subi Rijal, Vikash Paudel, Bhaskar M. M. Kayastha   +4 more
wiley   +1 more source

Successful Treatment With Spesolimab in a Haemodialysis Patient With Acutely Flaring Generalised Pustular Psoriasis

JEADV Clinical Practice
The efficacy and safety of biologics in patients with psoriasis and end‐stage renal disease is rarely reported. Here, we report a case of generalised pustular psoriasis (GPP) in a patient under haemodialysis successfully treated with spesolimab, with a ...
Yasuyuki Fujita, Sota Itamoto, Akihiro Orita, Kunihiro Kawashima, Satoko Shimizu   +4 more
doaj   +1 more source

Sequential Treatment of Generalized Pustular Psoriasis Combined with Bullous Pemphigoid Using Spesolimab and Dupilumab: A Case Report and Literature Review

Case Reports in Dermatology
Introduction: Generalized pustular psoriasis (GPP) and bullous pemphigoid (BP) are two distinct but occasionally coexisting inflammatory skin disorders. Their simultaneous presence presents diagnostic and therapeutic challenges. Spesolimab and
Ying Wang, Haoyu Yang, Zhihong Zhang, Hongda Yu, Lei Wang, Yanping Bai   +5 more
doaj   +1 more source