Results 51 to 60 of about 787 (175)

Dupilumab in Paediatric Netherton Syndrome: Two Case Reports and a Review of the Literature

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Netherton Syndrome (NS) is a rare genodermatosis characterised by a triad of ichthyosiform erythroderma, an atopic diathesis, and trichorrhexis invaginata, for which no effective management is currently approved in Australia. Dupilumab has demonstrated considerable effectiveness in the treatment of atopic conditions in the paediatric ...
Jacqueline Tu, Paul Sun Woo Kim, Kelvin Truong, Gloria Fong, William Luu, Li‐Chuen Wong   +5 more
wiley   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

Efficacy and safety of spesolimab in the treatment of Generalized Pustular Psoriasis: a systematic review. [PDF]

A psoríase pustulosa generalizada (PPG) é uma doença rara e potencialmente fatal, caracterizada por uma erupção generalizada de pústulas estéreis. O spesolimab é um novo anticorpo monoclonal que tem como alvo o recetor IL36RN, sendo dirigido para o ...
Cristiana Maria Louzada de Almeida
core   +1 more source

Early Real-Life Experience with Spesolimab in the Treatment of Generalized Pustular Psoriasis: A Case Series of Three Patients Treated in a Compassionate Use Program

Case Reports in Dermatology
Introduction: Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening form of psoriasis, characterized by widespread sterile pustules and systemic symptoms.
Anne Hald Rittig, Trine Bertelsen, Sascha Dinsen Wreschner Stave, Lars Iversen   +3 more
doaj   +1 more source

Real-world efficacy of spesolimab in treating generalized pustular psoriasis flares: A case series review

Dermatologica Sinica
This case series review examines the efficacy of spesolimab in managing generalized pustular psoriasis (GPP) flares, including those exacerbated by coronavirus disease 2019 (COVID-19) vaccination.
Chun-Bing Chen, Chun-Wei Lu, Chuang-Wei Wang, Wen-Hung Chung   +3 more
doaj   +1 more source

Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review

JCC Plus, Volume 1, Issue 5, September 2026.
This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz, Oguz Kagan Bakkaloglu, Nalan Gulsen Unal, Ismail Hakki Kalkan, Mehmet Arhan, Ibrahim Hatemi, Taylan Kav, Murat Toruner, Hale Akpinar, Ahmet Tezel, Aykut Ferhat Celik   +10 more
wiley   +1 more source

Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease [PDF]

, 2021
Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular psoriasis and psoriatic arthritis often represent a therapeutic challenge.
Puig Sanz, Lluís, Helena Iznardo, Lluís Puig, Iznardo, Helena   +3 more
core   +1 more source

Exploring the Clinical Assessment, Guidelines, and Options for the Treatment of Generalized Pustular Psoriasis [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Eingun James Song,1,* Clive Liu2,* 1Frontier Dermatology, Mill Creek, Washington, USA; 2Bellevue Dermatology Clinic, Bellevue, Washington, USA*These authors contributed equally to this workCorrespondence: Dr Eingun James Song, Email Eingun.Song ...
Song EJ, Liu C
doaj  

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Analysis of the German compassionate use program on spesolimab in patients with generalized pustular psoriasis: evidence outside of clinical trials [PDF]

Background Generalized pustular psoriasis (GPP) is a potentially life-threatening orphan disease. Interleukin (IL)-36 is a known pathogenetic key driver of GPP.
Thölken, Karisa, Krefting, Frederik, Thamm, Janis, Hölsken, Stefanie, Müller, Valentina Laura, Sondermann, Wiebke, Wohlrab, Johannes, Rueff, Franziska, Sticherling, Michael, Welzel, Julia, Kreuter, Alexander, Placke, Jan-Malte   +11 more
core   +1 more source