Results 31 to 40 of about 571 (112)

Exploring the Clinical Assessment, Guidelines, and Options for the Treatment of Generalized Pustular Psoriasis [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Eingun James Song,1,* Clive Liu2,* 1Frontier Dermatology, Mill Creek, Washington, USA; 2Bellevue Dermatology Clinic, Bellevue, Washington, USA*These authors contributed equally to this workCorrespondence: Dr Eingun James Song, Email Eingun.Song ...
Song EJ, Liu C
doaj  

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, Volume 5, Issue 2, Page 373-384, June 2026.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Expanding the therapeutic horizons of spesolimab: a review of off-label applications for inflammatory skin diseases

Journal of Dermatological Treatment
Purpose This review aims to outline the crucial role of IL-36 signaling in inflammatory skin diseases and summarize the therapeutic potential of spesolimab.
Hanlin Zhang, Jia Zhou, Keyun Tang, Xinyi Zhang, Hongzhong Jin   +4 more
doaj   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 963-979, June 2026.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault, Emilie Brenaut, Marie‐Emeline Marniquet, Carla Berthault, Lea Canoen, Clarisse Marcombes, Audrey Melin, Raphaël Ouakrat, Julie Charles, Stephane Mouret, Olivier Potie, Laetitia Penso, Laura Pina Vegas, Guillaume Larid, Marine Roux, Colombe Bougeard, Sandy Sylvain, Clara Labonne, Tania Randriamiarana, Da Hee Pitaud, Floriane Etheve, Jeremy Gottlieb, Laurie Gouillon, Marine Chastagner, Emilie Sbidian, Hélène Aubert, on behalf of the Psoriasis Research Group of the French Society of Dermatology (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), Hélène Aubert, Marie Masson Regnault, Emilie Brenaut, Emilie Sbidian, Laura Pina Vegas, Laetitia Penso, Jeremy Gottlieb, Marine Roux, Clara Labonne, Tania Randriamiarana, Floriane Etheve, Da Hee Pitaud, Marie‐Emeline Marniquet, Carla Berthault, Clarisse Marcombes, Audrey Melin, Colombe Bougeard, Julie Charles, Olivier Potie, Léa Canoen, Laurie Gouillon, Marine Chastagner, Sandy Sylvain, Guillaume Larid, Raphaël Ouakrat   +51 more
wiley   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Juvenile Generalized Pustular Psoriasis: Management in Children—A Case Series

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Juvenile Generalized Pustular Psoriasis (GPP) is an extremely rare and potentially life‐threatening inflammatory disease. We report three cases of Juvenile GPP that presented with recurrent episodes of widespread painful erythema with sterile pustules accompanied by fever and malaise.
Punam Mishra, Anupa Khadka
wiley   +1 more source

Palmoplantare Pustulose: Entstehung, Differentialdiagnose und Therapie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 516-536, April 2026.
Zusammenfassung Die palmoplantare Pustulose (PPP) ist eine chronisch entzündliche, häufig schmerzhafte Erkrankung mit sterilen Pusteln an Handflächen und Fußsohlen, die die Lebensqualität stark einschränkt. Frauen sind häufiger betroffen als Männer, und Rauchen ist ein bedeutender Provokationsfaktor.
Rotraut Mössner, Tanja Fetter, Robert Sabat, Ulrich Mrowietz, Neda Cramer, Dagmar Wilsmann‐Theis   +5 more
wiley   +1 more source

Treatment of generalized pustular psoriasis with Spesolimab: a case report and literature review

Pifu-xingbing zhenliaoxue zazhi
Objective To evaluate the efficacy and safety of Spesolimab in the treatment of generalized pustular psoriasis(GPP). Methods A 30 years old female with GPP was intravenously given 900 mg of Spesolimab once.
Xiaoqian LIANG, Zexi MI, Yaohan XU, Yongfeng CHEN   +3 more
doaj   +1 more source

Palmoplantar pustulosis: pathogenesis, differential diagnosis, and treatment

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 516-535, April 2026.
Summary Palmoplantar pustulosis (PPP) is a chronic inflammatory and often painful disease characterized by sterile pustules on the palms and soles, significantly impairing quality of life. Women are more frequently affected than men, and smoking is a major trigger. Under biologic therapies, especially TNF antagonists, a paradoxical PPP may occur.
Rotraut Mössner, Tanja Fetter, Robert Sabat, Ulrich Mrowietz, Neda Cramer, Dagmar Wilsmann‐Theis   +5 more
wiley   +1 more source

Exploring the Quality-of-Life Impact, Disease Burden, and Management Challenges of GPP: The Provider and Patient Perspective [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Jason E Hawkes,1,* Dale V Reisner,2 Tina Bhutani3,* 1Department of Dermatology, University of California at Davis, Sacramento, CA, USA; 2Patient Author, Yankton, SD, USA; 3Psoriasis and Skin Treatment Center, Department of Dermatology, University
Hawkes JE, Reisner DV, Bhutani T
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