Results 21 to 30 of about 571 (112)

Long-term control of refractory acrodermatitis continua of Hallopeau with subcutaneous spesolimab: A case report [PDF]

JAAD Case Reports
Jan Nicolai Wagner, MD, Franziska Zirkenbach, MD, Brigtte Stephan, MD, Carolin Grote, MD, Matthias Augustin, Prof. Dr med   +4 more
doaj   +2 more sources

Spesolimab Rapidly Resolved Capillary Leak Syndrome Associated with Generalized Pustular Psoriasis

Acta Dermato-Venereologica
Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada   +4 more
doaj   +2 more sources

The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab

Frontiers in Immunology, 2023
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder characterized by recurrent flares associated with skin erythema, desquamation, and widespread superficial sterile pustules, which may be severe (“lakes of pus”). Systemic
Jason E. Hawkes, Sudha Visvanathan, James G. Krueger   +2 more
doaj   +1 more source

First experiences in real clinical practice treating a patient with generalised pustular psoriasis with Spesolimab

JEADV Clinical Practice, 2023
Generalised pustular psoriasis is a rare, unpredictable, and sometimes severe subtype of psoriasis whose treatment is hampered by a lack of consensus and standardised therapeutic guidelines.
Aurora Fernández‐Galván, Esteban Daudén, Beatriz Butron‐Bris, Mireia Seguí‐Olmedilla, Ana Miguélez, Javier Fraga, Pedro Rodríguez Jiménez, Mar Llamas‐Velasco   +7 more
doaj   +1 more source

Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare

BMJ Open, 2021
Introduction Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterised by recurrent flares of widespread neutrophilic aseptic skin pustular eruption. Despite the availability of approved biologics for GPP in Japan,
Hamida Turki, Akimichi Morita, Min Zheng, Tsen-Fang Tsai, Siew Eng Choon, Mark G Lebwohl, Slaheddine Marrakchi, A David Burden, Alexander A Navarini, Jinhua Xu, Sushmita Rajeswari, Hongjie Deng, Kay Tetzlaff, Christian Thoma, Hervé Bachelez   +14 more
doaj   +1 more source

Generalized Pustular Psoriasis with Breast Cancer Successfully Treated with Spesolimab Causing Neutrophilia: A Case Report [PDF]

Acta Dermato-Venereologica
Rina Obata, Mika Yamanaka-Takaichi, Hisayoshi Imanishi, Tomoko Oshimo, Daisuke Tsuruta   +4 more
doaj   +2 more sources

Spesolimab for a child with generalized pustular psoriasis accompanied epilepsy and hyperactivity

Journal of Dermatological Treatment
Objectives To evaluate the therapeutic efficacy and safety of spesolimab in pediatric GPP treatment.Methods We report a 10-year-old male pediatric patient with refractory Generalized Pustular Psoriasis (GPP), comorbid epilepsy, hyperactivity ...
Yudan Wang, Jie Qin, Li Peng, Linli He, Beichen Yang, Mei Yang, Yanyan Feng   +6 more
doaj   +1 more source

Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study [PDF]

Acta Dermato-Venereologica
Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada   +4 more
doaj   +2 more sources

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

Real-world efficacy of spesolimab in treating generalized pustular psoriasis flares: A case series review

Dermatologica Sinica
This case series review examines the efficacy of spesolimab in managing generalized pustular psoriasis (GPP) flares, including those exacerbated by coronavirus disease 2019 (COVID-19) vaccination.
Chun-Bing Chen, Chun-Wei Lu, Chuang-Wei Wang, Wen-Hung Chung   +3 more
doaj   +1 more source