Results 21 to 30 of about 787 (175)

Successful treatment of etanercept- and adalimumab-resistant pyoderma gangrenosum with spesolimab, moderate-dose corticosteroids, and minocycline

Journal of Dermatological Treatment
Purpose Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis characterized by rapidly developing, painful ulcers. This study explores the potential of spesolimab, an anti-IL-36R antibody, as a therapeutic option for refractory PG.Materials and ...
Hanlin Zhang, Hongzhong Jin
exaly   +3 more sources

Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report [PDF]

Frontiers in Immunology
Generalized pustular psoriasis (GPP) is a rare chronic inflammatory pustular dermatosis that presents as painful erythema with sterile pustules on nonacral skin. No unified standard and guideline for the treatment of GPP has been established.
Pengfei Wen, Chuan Liu, Tingting Wang, Xian Jiang, Ping Wang, Sheng Wang   +5 more
doaj   +2 more sources

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights [PDF]

Frontiers in Immunology
A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH).
Xin-Yi Hou, Hai-Lu Xiao, Jing-Yu Wang, Jin Zhang, Bo Ren, Chu-chu Niu, Fei-Fei Liu, Bin Lu   +7 more
doaj   +2 more sources

Generalized Pustular Psoriasis During Early Pregnancy Successfully Treated with Spesolimab: A Case Report [PDF]

International Medical Case Reports Journal
Xinlong Chen, Degui Chang, Chenjian Tang Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Chenjian Tang, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s ...
Chen X, Chang D, Tang C
doaj   +2 more sources

Spesolimab use in treatment of pyoderma gangrenosum

JAAD Case Reports, 2023
Sophie H. Guénin, MSc, Saakshi Khattri, MD, Mark G. Lebwohl, MD   +2 more
doaj   +3 more sources

Achieving Therapeutic Success with Spesolimab: Two Cases of Drug-Induced Generalized Pustular Psoriasis Initially Mimicking Acute Generalized Exanthematous Pustulosis [PDF]

Journal of Inflammation Research
Jianxia Chen,1,* Yuting Xia,2,3,* Faqiong Zhou,1 Juan Tao,2,3 Nuoya Zhou2,3 1Department of Dermatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, People’s Republic of China; 2Department of ...
Chen J, Xia Y, Zhou F, Tao J, Zhou N
doaj   +2 more sources

Case Report: Spesolimab for pyoderma gangrenosum in an undifferentiated oligoarthritis patient receiving anti-IL-17 therapy

Frontiers in Immunology
Pyoderma gangrenosum (PG) is a classic neutrophilic dermatosis often associated with inflammatory conditions, frequently leading to misdiagnosis and delayed treatment. Drug-induced and postoperative are two potential triggers of PG.
Fang Du, Liyang Gu
exaly   +3 more sources

Therapeutic Potential of Spesolimab-Sbzo in the Management of Generalized Pustular Psoriasis Flares in Adults: Evidence to Date

Psoriasis: Targets and Therapy
Federica Rega, Federica Trovato, Giulio Bortone, Giovanni Pellacani, Antonio Giovanni Richetta, Annunziata Dattola Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome ...
Annunziata Dattola, Giovanni Pellacani, Federica Rega   +2 more
exaly   +2 more sources

Subcutaneous Spesolimab for Amicrobial Pustulosis of the Folds. [PDF]

Int J Dermatol
Marzano AV, Bettolini L, Derlino F, Sarno L, Buffon S, Genovese G, Boggio FL, Moltrasio C, Pilliu A, Brevi M, Maronese CA.   +10 more
europepmc   +2 more sources

Early Temporal Dissociation Between C-Reactive Protein and Neutrophil Counts After Spesolimab Treatment in Generalized Pustular Psoriasis [PDF]

Acta Dermato-Venereologica
Ayu Watanabe, Masahiro Kamata, Yoshiki Okada, Kotaro Hayashi, Yayoi Tada   +4 more
doaj   +2 more sources