Results 41 to 50 of about 571 (112)

Aseptic meningitis due to intravenous immunoglobulin therapy (IVIG) in therapy‐refractory pyoderma gangraenosum

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katharina A. Kälber, Knut Schäkel, Alexander Enk, Julia K. Winkler   +3 more
wiley   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, Volume 268, Issue 3, Page 249-262, March 2026.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Severe generalized pustular psoriasis complicated with staphylococcal toxic shock syndrome treated with spesolimab and antibiotics

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Spyridon Gkalpakiotis, Jan Hugo, Natalie Michalik, Robert Zajicek, Cecilie Stonova, Bohumil Bakalar   +5 more
wiley   +1 more source

Bilateral Idiopathic Pyoderma Gangrenosum: A Case Report of an Atypical Presentation

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Pyoderma gangrenosum (PG) is a rare non‐infectious neutrophilic dermatosis which is characterized by a rapidly progressive, painful ulcer. Bilateral manifestation of PG is exceptionally rare and can easily be misdiagnosed as infection or vascular ulceration, delaying proper treatment.
Sanjog Thapa Magar, Deekshanta Sitaula, Subi Rijal, Vikash Paudel, Bhaskar M. M. Kayastha   +4 more
wiley   +1 more source

Dysregulation of Microbiome and Lipid Metabolism With Unusual Folliculosebaceous Presentations in the External Ear of Patients With Hidradenitis Suppurativa

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Hidradenitis suppurativa (HS) primarily occurs in intertriginous areas where apocrine sweat glands are densely distributed. The external ear, including ceruminous glands, a type of modified apocrine sweat gland, and its microbiome and lipidomic features, remains underexplored.
Qian Ye, Zheng Hou, Ruojun Wang, Chong Zhang, Yan Yang, Yi Li, Baoxi Wang, Yan Yan, Suraiya Saleem   +8 more
wiley   +1 more source

Successful Treatment With Spesolimab in a Haemodialysis Patient With Acutely Flaring Generalised Pustular Psoriasis

JEADV Clinical Practice
The efficacy and safety of biologics in patients with psoriasis and end‐stage renal disease is rarely reported. Here, we report a case of generalised pustular psoriasis (GPP) in a patient under haemodialysis successfully treated with spesolimab, with a ...
Yasuyuki Fujita, Sota Itamoto, Akihiro Orita, Kunihiro Kawashima, Satoko Shimizu   +4 more
doaj   +1 more source

Serum IL‐36 Cytokine Profile in Adult Patients With Acne Vulgaris: A Case–Control Study

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction and Objective Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit characterized by complex immunological mechanisms. The interleukin‐36 (IL‐36) cytokine family has been implicated in various inflammatory skin disorders; however, its role in adult AV remains insufficiently defined.
Ayşegül Yalçınkaya İyidal, Yıldız Hayran, Akın Aktaş, Esra Fırat Oğuz, Suraiya Saleem   +4 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Cross-spectrum efficacy of spesolimab in IL-36-mediated dermatoses: a ′case study

Journal of Dermatological Treatment
Background The nosological distinction between acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) has become increasingly unclear due to shared IL-36 pathway dysregulation.
RuoYan Tong, ChaoChao Chen, Ling Huang, ChangWen Ni   +3 more
doaj   +1 more source

Treatment of Pyoderma Gangrenosum With Bimekizumab

JEADV Clinical Practice, Volume 4, Issue 5, Page 1174-1177, December 2025.
ABSTRACT Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with no FDA‐approved treatments. Current therapies, including corticosteroids and immunomodulators, often show limited efficacy and nonspecific, conferring to higher risk of adverse events.
Kareena S. Garg, Adeel Ahmad, Leonardo Tjahjono   +2 more
wiley   +1 more source