Spesolimab for treatment of generalized pustular psoriasis of pregnancy
PregnancyIntroduction Generalized pustular psoriasis (GPP) is a severe, desquamating skin disorder associated with pregnancy that presents as fever, fatigue, malaise and sterile pustules.
Jason Bunn +9 more
doaj +2 more sources
Journal of Dermatological TreatmentPurpose Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis characterized by rapidly developing, painful ulcers. This study explores the potential of spesolimab, an anti-IL-36R antibody, as a therapeutic option for refractory PG.Materials and ...
Hongzhong Jin
exaly +3 more sources
Frontiers in ImmunologyGeneralized pustular psoriasis (GPP) is a rare chronic inflammatory pustular dermatosis that presents as painful erythema with sterile pustules on nonacral skin. No unified standard and guideline for the treatment of GPP has been established.
Pengfei Wen, Xian Jiang, Jiang Xian
exaly +3 more sources
Generalized Pustular Psoriasis During Early Pregnancy Successfully Treated with Spesolimab: A Case Report [PDF]
International Medical Case Reports JournalXinlong Chen, Degui Chang, Chenjian Tang Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Chenjian Tang, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s ...
Chen X, Chang D, Tang C
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Achieving Therapeutic Success with Spesolimab: Two Cases of Drug-Induced Generalized Pustular Psoriasis Initially Mimicking Acute Generalized Exanthematous Pustulosis [PDF]
Journal of Inflammation ResearchJianxia Chen,1,* Yuting Xia,2,3,* Faqiong Zhou,1 Juan Tao,2,3 Nuoya Zhou2,3 1Department of Dermatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, People’s Republic of China; 2Department of ...
Chen J, Xia Y, Zhou F, Tao J, Zhou N
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Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights [PDF]
Frontiers in ImmunologyA 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH).
Xin-Yi Hou +7 more
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Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab
Journal of Dermatological TreatmentGeneralized pustular psoriasis (GPP) in pregnancy can lead to severe complications for both mother and fetus. The treatment of this disease is challenging, especially in recalcitrant and severe cases. Until present, there are no evidence-based guidelines
Ruoyu Li
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Psoriasis: Targets and TherapyFederica Rega, Federica Trovato, Giulio Bortone, Giovanni Pellacani, Antonio Giovanni Richetta, Annunziata Dattola Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome ...
Giovanni Pellacani, Annunziata Dattola
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Real-World Safety Profile of Spesolimab in Generalized Pustular Psoriasis: Insights From Japan as Part of a Multinational Expanded Access Program (EAP). [PDF]
J DermatolABSTRACT Generalized pustular psoriasis (GPP) is a heterogeneous, systemic neutrophilic inflammatory disease, characterized by chronic symptoms and recurrent flares, which can be potentially life‐threatening. Spesolimab, an interleukin‐36 receptor antagonist, has been approved to treat GPP flares in many countries including Japan.
Morita A +12 more
europepmc +2 more sources
Correction to "Successful Treatment With Spesolimab in a Haemodialysis Patient With Acutely Flaring Generalised Pustular Psoriasis". [PDF]
JEADV Clin PractJEADV Clinical Practice, Volume 5, Issue 1, Page 349-349, March 2026.
europepmc +2 more sources