Results 81 to 90 of about 1,019 (188)

Treatment of Pyoderma Gangrenosum With Bimekizumab

JEADV Clinical Practice, Volume 4, Issue 5, Page 1174-1177, December 2025.
ABSTRACT Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with no FDA‐approved treatments. Current therapies, including corticosteroids and immunomodulators, often show limited efficacy and nonspecific, conferring to higher risk of adverse events.
Kareena S. Garg, Adeel Ahmad, Leonardo Tjahjono   +2 more
wiley   +1 more source

Treatment of generalized pustular psoriasis with Spesolimab: a case report and literature review

Pifu-xingbing zhenliaoxue zazhi
Objective To evaluate the efficacy and safety of Spesolimab in the treatment of generalized pustular psoriasis(GPP). Methods A 30 years old female with GPP was intravenously given 900 mg of Spesolimab once.
Xiaoqian LIANG, Zexi MI, Yaohan XU, Yongfeng CHEN   +3 more
doaj   +1 more source

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study [PDF]

, 2023
Background: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by recurrent episodes of flares. Characteristics of patients experiencing a flare are hardly described in a real-life setting. The aim of the study
Aldo Cuccia, Andrea Carugno, Angelo Valerio Marzano, Antonio Costanzo, Clara De Simone, Elena Pezzolo, Francesca Prignano, Francesca Satolli, Francesco Bellinato, Giampiero Girolomoni, Giovanni Damiani, Giuseppe Argenziano, Marco Romanelli, Marina Venturini, Martina Burlando, Matteo Megna, Paolo Dapavo, Paolo Gisondi, Stefano Piaserico   +18 more
core   +3 more sources

Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval

Frontiers in Immunology
Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening inflammatory disease, characterized by the rapid and widespread eruption of small, sterile pustules with surrounding skin erythema.
Eran C. Gwillim, Eran C. Gwillim, Anna J. Nichols   +2 more
doaj   +1 more source

Nuevas estrategias terapéuticas en la psoriasis [PDF]

, 2023
La psoriasis es una afección dermatológica inflamatoria crónica, inmunomediada, caracterizada por la hiperproliferación de queratinocitos y lesiones eritematosas y descamativas. Hay alrededor de 60 millones de pacientes afectados en el mundo.
Frade Cerezales, Andrea
core  

Therapeutic potential of targeting interleukin-1 family cytokines in chronic inflammatory skin diseases* [PDF]

, 2022
The interleukin (IL)-1 family of cytokines is a central regulator of a myriad of immunological responses. It comprises several cytokines, including those belonging to the IL-1, IL-36 and IL-18 subfamilies, as well as IL-33.
Calabrese L., Fiocco Z., French L. E., Peris K., Satoh T. K.   +4 more
core   +1 more source

How to Evaluate Fibrosis in IBD? [PDF]

, 2023
In this review, we will describe the importance of fibrosis in inflammatory bowel disease (IBD) by discussing its distinct impact on Crohn's disease (CD) and ulcerative colitis (UC) through their translation to histopathology.
Magro, Fernando, Sousa, Helena Tavares
core   +1 more source

Exploring the Quality-of-Life Impact, Disease Burden, and Management Challenges of GPP: The Provider and Patient Perspective [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Jason E Hawkes,1,* Dale V Reisner,2 Tina Bhutani3,* 1Department of Dermatology, University of California at Davis, Sacramento, CA, USA; 2Patient Author, Yankton, SD, USA; 3Psoriasis and Skin Treatment Center, Department of Dermatology, University
Hawkes JE, Reisner DV, Bhutani T
doaj  

A Methodical Approach to a 15-Year Diagnostic Enigma: Unmasking Acrodermatitis Continua of Hallopeau Through Dermoscopy, Histopathology, and Structured Therapeutic Sequencing [PDF]

Background: Acrodermatitis continua of Hallopeau (ACH) is a rare, debilitating variant of pustular psoriasis. Its profound clinical mimicry of common infections, particularly onychomycosis, often leads to extensive diagnostic delays and ineffective ...
Luh Putu Sustiana Kartika Sari, Ni Luh Putu Ratih Vibriyanti Karna   +1 more
core   +2 more sources

Evaluation of Neutrophil Activity Before and After Granulocyte and Monocyte Adsorptive Apheresis in Patients With Pustular Psoriasis

Therapeutic Apheresis and Dialysis, Volume 29, Issue 4, Page 702-706, August 2025.
ABSTRACT Introduction Activated neutrophils play a crucial role in the development of neutrophilic dermatoses, including pustular psoriasis. Adsorptive granulocyte and monocyte apheresis (GMA) is an effective treatment for skin disorders. Although previous basic research has demonstrated neutrophil activation, no efficient method exists to assess it in
Yuko Higashi, Atsuko Ibusuki, Tomoko Fukushige, Ryoko Sagara, Risako Yonezawa, Natsumi Terada, Hisao Kawahira, Kimiko Kazumura, Takuro Kanekura   +8 more
wiley   +1 more source