Results 221 to 230 of about 67,710 (307)

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

A 3-dimensional Resnet model for assessment of drug efficacy in 3D cancer models using optical coherence tomography. [PDF]

PLoS One
Untracht GR, Kaminski J, Guldenring E, Nielsen BS, Holmstrøm K, Jensen KH, Andersen PE.   +6 more
europepmc   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Matrix Stiffness Modulates 3D Spheroid-Derived Extracellular Vesicle Profiles and Discovery of Piezo1 Cargo. [PDF]

Cell Mol Bioeng
Sheth M, Kongsomros S, Sharma M, Lehn M, Takebe T, Takiar V, Wise-Draper T, Chutipongtanate S, Esfandiari L.   +8 more
europepmc   +1 more source

Can spheroid formation enhance mesenchymal stem cell homing in veterinary medicine? Insights and evidence gaps

Frontiers in Veterinary Science
Leonardo Martin, Leonardo Martin, Leonardo Martin, Guido R. Y. De Meyer, Guido R. Y. De Meyer, Guido R. Y. De Meyer   +5 more
doaj   +1 more source

Beyond monolayers: a comparative analysis of 2D cell cultures and 3D <i>in vitro</i> models as new approach methodologies. [PDF]

Front Bioeng Biotechnol
Calori IR, Guimaraes APP, Kammala AK, Richardson LS, Menon R.   +4 more
europepmc   +1 more source

Assessing drug-induced liver injury liabilities in human and animal hepatocytes under static and perfused spheroid culture conditions. [PDF]

Toxicol Sci
Negi CK, Chan CLT, Tsai HD, Alshammari I, Sakolish C, Chiu WA, Hewitt P, Ferguson SS, Villenave R, Bitounis D, Rusyn I.   +10 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Genotype-Informed Whole-Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC. [PDF]

Cancer Sci
Hai H, Ooshio T, Jiang H, Kimura T, Satoh Y, Hata S, Hirata T, Liu J, Liu T, Yamamura R, Sonoshita M.   +10 more
europepmc   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source