Results 231 to 240 of about 79,551 (308)

Advancing genotoxicity assessment with transcriptomic biomarkers: from 2D to 3D HepaRG spheroid models. [PDF]

Toxicol Sci
Saleh M, Hogeveen K, Thienpont A, Demuynck E, Fessard V, Mertens B, Le Hégarat L.   +6 more
europepmc   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Cell-derived lactate triggers local hydrogelation and phenotype remodelling. [PDF]

Nat Commun
Braun MG, Schneider TC, Koynov K, Gieß S, Driehaus-Ortiz L, Förch L, Schuler M, Wagner M, Synatschke CV, Régnier-Vigouroux A, De Laporte L, Ng DYW, Weil T.   +12 more
europepmc   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Gene Expression of <i>TGF-β1</i>, Matrix Metalloproteinases, and Collagen in Keloid Patients and Their Growth Patterns in 2D and 3D Cell Cultures: An <i>In Vitro</i> Study. [PDF]

In Vivo
Helmer A, Kern J, Prohaska P, Sadick H, Kramer B, Zaubitzer L, Schell A, Rotter N, Häussler D.   +8 more
europepmc   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

CTGF/CCN2 Promotes Invasive Growth in Cervical Cancer Spheroids and Is Associated With Metastatic Cervical Cancer Tissue. [PDF]

Cancer Genomics Proteomics
VON DER Brelie L, Kalyoncu NG, Gallwas J, Gründker C.   +3 more
europepmc   +1 more source

A Water Compartment Cell Culture Lid Enables Stable Longitudinal Recording of Neuronal Networks In Vitro

Advanced Science, EarlyView.
A cell culture lid with an integrated water compartment eliminates evaporation from microelectrode arrays while preserving gas exchange. Freed from the osmotic drift and repeated medium exchanges that disturb conventional recordings, patterned human iPSC‐derived neuronal networks are recorded continuously for five weeks. Single‐spike resolution reveals
Benedikt Maurer, Fabio Fischer, Giulia Amos, Vaiva Vasiliauskaitė, János Vörös   +4 more
wiley   +1 more source