Results 101 to 110 of about 68,956 (338)

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2

, 2018
Saccharomyces cerevisiae target of rapamycin (TOR) complex 2 (TORC2) is an essential regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is modulated in response to changes in the status of the cell envelope is unclear. Here we
Augustin, Christoph M., Emmerstorfer-Augustin, Anita, Hill, Jennifer M., Leskoske, Kristin L., Roelants, Françoise M., Si, Edward P., Thorner, Jeremy   +6 more
core   +1 more source

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

Sphingolipid metabolism diseases

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Human diseases caused by alterations in the metabolism of sphingolipids or glycosphingolipids are mainly disorders of the degradation of these compounds. The sphingolipidoses are a group of monogenic inherited diseases caused by defects in the system of lysosomal sphingolipid degradation, with subsequent accumulation of non-degradable storage material ...
Thomas Kolter, Konrad Sandhoff
openaire   +3 more sources

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Journal of Lipid Research, 2019
Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalyzed reactions.
Peter J. Harrison, Kenneth Gable, Niranjanakumari Somashekarappa, Van Kelly, David J. Clarke, James H. Naismith, Teresa M. Dunn, Dominic J. Campopiano   +7 more
doaj   +1 more source

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea, Koch, Alexander, Pfeilschifter, Josef Martin   +2 more
core   +2 more sources

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

Advanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu   +13 more
wiley   +1 more source

Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate

Biomolecules, 2020
Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence contributes to a median survival of only 15 months with the current standard
Cyntanna C. Hawkins, Tomader Ali, Sasanka Ramanadham, Anita B. Hjelmeland   +3 more
doaj   +1 more source

Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability [PDF]

, 2018
Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle ...
Barrantes, Francisco Jose, Camino, Pablo A., Mosqueira, Alejo   +2 more
core   +2 more sources