Results 121 to 130 of about 52,400 (306)

CYTOTOXIC EFFECTS OF PERIFOSINE IN HUMAN GLIOBLASTOMA CELLSARE ASSOCIATED TO AN ALTERED CERAMIDE METABOLISM

, 2013
Background: Glioblastoma multiforme (GBM) is the most malignant brain tumor and, despite aggressive therapy, prognosis for patients is poor. Temozolomide (TMZ), the chosen drug in GBM therapy, exerts cytotoxic effects also through an increase of ceramide
P. Giussani, A. Cinque, P. Viani, L. Riboni, L. Brioschi   +4 more
core  

Differential regulation of sphingolipid metabolism in plasma, hippocampus and cerebral cortex of mice administered sphingolipid modulating agents

, 2017
Accumulation of ceramide is implicated in mediating the cellular responses to stress and aberrant sphingolipid metabolism is frequently associated with metabolic and neurodegenerative diseases.
Mamo, John, Dhaliwal, Satvinder, Takechi, Ryu, Mamo, JC, Takechi, R, Giles, C, Giles, Corey, Meikle, P., Mellett, NA, Meikle, PJ, Dhaliwal, S, Mellett, N.   +11 more
core   +1 more source

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

iMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang, Xiaopeng Wang, Peng Li, Junyu Zhang, Wenjie Sun, Zhen Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen   +8 more
wiley   +1 more source

Overview of core sphingolipid pathways.

, 2018
The sphingolipids analysed in our study are highly interconnected and play central roles in sphingolipid metabolism.
Katja Jakobi (5979359), Marcus Maximilian Mücke (5979365), Viola Knop (5979362), Georgios Grammatikos (587271), Kai-Henrik Peiffer (2826029), Josef Pfeilschifter (92946), Victoria Therese Mücke (5979356), Dominique Thomas (3084342), Christoph Sarrazin (48298), Stefan Zeuzem (22856)   +9 more
core   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Opaganib Promotes Weight Loss and Suppresses High-Fat Diet-Induced Obesity and Glucose Intolerance

Diabetes, Metabolic Syndrome and Obesity
Lynn W Maines, Staci N Keller, Ryan A Smith, Charles D Smith Apogee Biotechnology Corporation, Hummelstown, PA, USACorrespondence: Charles D Smith, Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA, 17036, USA, Email ...
Maines LW, Keller SN, Smith RA, Smith CD
doaj  

Editorial: Activation of Innate Immunity by Allergens and Allergenic Sources

Frontiers in Allergy, 2021
Fatima Ferreira, Geoffrey A. Mueller, Stefanie Gilles, Stefanie Gilles, Marsha Wills-Karp   +4 more
doaj   +1 more source

Sphingolipid concentration in plasma of African-American SLE patients with atherosclerosis compared to sphingolipid concentration in plasma of African-American SLE patients without atherosclerosis and to sphingolipid concentration in White SLE patients with atherosclerosis presented in Table 4.

, 2019
Sphingolipid concentration in plasma of African-American SLE patients with atherosclerosis compared to sphingolipid concentration in plasma of African-American SLE patients without atherosclerosis and to sphingolipid concentration in White SLE patients ...
Paul J. Nietert (7901111), Dulaney A. Wilson (7901105), Jasmyn R. Hardin (7901102), James C. Oates (7901114), Waleed O. Twal (7901108), Samar M. Hammad (7901099)   +5 more
core   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source