Results 281 to 290 of about 68,956 (338)

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, Volume 157, Issue 7, Page 1304-1315, 1 October 2025.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Ceramides play a significant role in the response of Pogostemon cablin to bacterial wilt by regulating the ABA pathway. [PDF]

BMC Plant Biol
Li J, Wu DX, Bao HN, Li KY, Zhang MY, Sun YH, Xia KF.   +6 more
europepmc   +1 more source

Lipedema: Progress, Challenges, and the Road Ahead

Obesity Reviews, Volume 26, Issue 10, October 2025.
ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley   +1 more source

How do different cell populations orchestrate myelin regeneration? [PDF]

Biochem Soc Trans
Grassi S, Prinetti A.
europepmc   +1 more source

KLF9 Inhibits Brain Metastasis of Non‐Small Cell Lung Cancer by Regulating Ceramide Synthase 1 Synthesis

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
This study reports KLF9's direct control over Cers1 expression by acting on its promoter. KLF9 demonstrates inhibitory effects on NSCLC BM, presenting a promising therapeutic avenue for NSCLC BM treatment. ABSTRACT The regulatory mechanisms driving brain metastasis (BM) in non‐small cell lung cancer (NSCLC) are complex, with Ceramide synthase 1 (Cers1)
Yingqiu He, Junfan Pan, Sufang Chen, Ying Lin, Peiwei She, Yusheng Chen, Nengluan Xu, Hongru Li   +7 more
wiley   +1 more source

Exploring sphingolipid metabolism-related biomarkers for Parkinson's disease: a transcriptomic analysis. [PDF]

Front Neurol
Wang G, Zhou X.
europepmc   +1 more source

Microbial diversity and function in the rhizosphere microbiome: Driving forces and monitoring approaches

Agrosystems, Geosciences &Environment, Volume 8, Issue 3, September 2025.
Abstract As an ecological unit, the rhizosphere microbiome preserves an enormous and largely unexplored diversity of microbes that play essential roles in plant health and soil functions. Omics technologies encompassing high‐throughput approaches such as metagenomics, metatranscriptomics, and metaproteomics provide helpful tools to unravel the ...
Chinenyenwa Fortune Chukwuneme, Olubukola Oluranti Babalola   +1 more
wiley   +1 more source

Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor. [PDF]

Front Immunol
Wu F, Feng Z, Wang X, Guo Y, Wu B, Bai S, Lan N, Chen M, Ren J.   +8 more
europepmc   +1 more source

Lipid Dysregulation in Sebaceous Gland Disorders and the Impact of Sphingolipid Metabolism on Acne Pathogenesis. [PDF]

Cureus
Miner K, Murphy R, Steiss S, Burian M, Welp H, Loperfito A, O'Malley A, Misra R, Frasier KM.   +8 more
europepmc   +1 more source

Investigating the Impact of Aspartame on Ulcerative Colitis Through Network Toxicology and Molecular Docking

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Through the application of network toxicology and molecular ligation, this study elucidates that aspartame may influence the progression of ulcerative colitis by targeting molecules such as BCL2, TNF, and CASP3, thereby modulating pathways related to inflammation and apoptosis, including the C‐type lectin receptor, sphingolipids, and VEGF pathways ...
Lili Ge, Lei Ma, Zhi Jin
wiley   +1 more source