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Sphingolipid

2023
Sphingolipids are a class of lipids containing the backbone of long-chain amino-alcohol bases in their structure, which are synthesized in the endoplasmic reticulum. Modification of this base gives rise to a variety of such lipids ranging from simple to complex sphingolipids that play a significant structural and functional role in membrane biology as ...
Shaista Nosheen   +3 more
openaire   +1 more source

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

Science, 1989
The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction.
Y A, Hannun, R M, Bell
openaire   +2 more sources

Sphingolipids in inflammatory hypoxia

Biological Chemistry, 2018
Abstract Hypoxia due to rapid tumor growth with impaired neovascularization and inflammation resulting from immune cell activation are hallmarks of cancer. Hypoxia-inducible factors control transcriptional adaptation in response to low oxygen conditions, both in tumor and immune cells.
Glaser, Ulrike G, Fandrey, Joachim
openaire   +3 more sources

A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis

International Journal of Molecular Sciences, 2021
Natalie M Deschenes, Jagdeep S Walia
exaly  

Sphingolipids

Annual Review of Biochemistry, 1971
openaire   +2 more sources

Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity

American Journal of Respiratory Cell and Molecular Biology, 2020
Arul Veerappan   +2 more
exaly  

Sphingolipid-binding proteins

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2006
Yusuf A Hannun, Y A Hannun
exaly  

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