Results 291 to 300 of about 68,956 (338)

Mechanistic insights into the therapeutic effects on liver fibrosis in Wilson's disease: a transcriptomic and network pharmacology-based approach. [PDF]

Front Med (Lausanne)
Ma Y, Pu Y, Chen H, Zhou L, Yang B, Huang X, Zhang J.   +6 more
europepmc   +1 more source

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

MedComm, Volume 6, Issue 9, September 2025.
Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng, Yu‐jia Zhao, Ce Chen, Feng Zhang   +3 more
wiley   +1 more source

Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug. [PDF]

Reprod Biol Endocrinol
Shi W, Lin H, Di W, He C, Shen Y.
europepmc   +1 more source

Phytosphingosine Alleviates Cigarette Smoke‐Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4

MedComm, Volume 6, Issue 9, September 2025.
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a complex and irreversible respiratory disorder with a poor prognosis and a lack of effective pharmaceutical treatment. Our previous metabolomics study identified phytosphingosine (PHS) as a key differential metabolite in COPD that is positively correlated with lung function.
Yuan Zhan, Zhesong Deng, Ruonan Yang, Shanshan Chen, Jiaheng Zhang, Yating Zhang, Hao Fu, Qian Huang, Yiya Gu, Zhilin Zeng, Jinkun Chen, Jixian Zhang, Jixing Wu, Jungang Xie   +13 more
wiley   +1 more source

Diabetic Ketoacidosis Is Associated with Lower Serum Sphingolipids but Higher β-Hydroxybutyrate and Lactate: A Pilot Study. [PDF]

Pathophysiology
Aslan I, Çeker T, Ustabaş T, Zorlu V, Yılmaz Ç, Aslan M.   +5 more
europepmc   +1 more source

Polarization of Tumor Cells and Tumor‐Associated Macrophages: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Bidirectional metabolic interactions between tumor cells and TAMs in the TME metabolic reprogramming facilitates reciprocal crosstalk between TAMs and tumor cells within the immunosuppressive TME. This interaction promotes both the pro‐tumor functions of TAMs and tumor mesenchymal transition through complex molecular signaling.
Guohao Wei, Bin Li, Mengyang Huang, Mengyao Lv, Zihui Liang, Chuandong Zhu, Lilin Ge, Jing Chen   +7 more
wiley   +1 more source

Drug Resistance: The Role of Sphingolipid Metabolism. [PDF]

Int J Mol Sci
Zhakupova A, Zeinolla A, Kokabi K, Sergazy S, Aljofan M.   +4 more
europepmc   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia. [PDF]

Cell Death Dis
Xie Y, Zeng Q, Chen Z, Song J, Wang F, Liu D, Sun X, Zhang Y, Huang Q.   +8 more
europepmc   +1 more source

Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach

Smart Medicine, Volume 4, Issue 3, September 2025.
Untargeted metabolomics is used to analyze tissue samples from chronic suppurative otitis media patients with or without cholesteatoma and identify metabolic differences across groups stratified by CT scores. Targeted metabolomic validation in an independent cohort verified five candidate metabolites. ABSTRACT Chronic suppurative otitis media (CSOM) is
Lidan Hu, Yifan Zhu, Chengpeng Wu, Xiao Liu, Qi Wang, Yangyiyi Huang, Hongyan Liu, Xiangjun Chen, Wei Wu, Hua Jiang   +9 more
wiley   +1 more source