Results 71 to 80 of about 68,956 (338)

Single-cell sequencing analysis related to sphingolipid metabolism guides immunotherapy and prognosis of skin cutaneous melanoma

Frontiers in Immunology, 2023
BackgroundWe explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked to aggressive behavior in various cancers, including SKCM.
Yantao Ding, Yantao Ding, Yantao Ding, Zhijie Zhao, Huabao Cai, Yi Zhou, Yi Zhou, Yi Zhou, He Chen, Yun Bai, Zhenran Liu, Shengxiu Liu, Shengxiu Liu, Shengxiu Liu, Wenming Zhou, Wenming Zhou, Wenming Zhou   +16 more
doaj   +1 more source

The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]

, 2007
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu, Periasamy Selvaraj, Timothy P. Tolentino   +2 more
core   +2 more sources

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia[S]

Journal of Lipid Research, 2010
Synthesis of glucosylceramide via glucosylceramide synthase (GCS) is a crucial event in higher eukaryotes, both for the production of complex glycosphingolipids and for regulating cellular levels of ceramide, a potent antiproliferative second messenger ...
Saša Štefanić, Cornelia Spycher, Laura Morf, Gemma Fabriàs, Josefina Casas, Elisabeth Schraner, Peter Wild, Adrian B. Hehl, Sabrina Sonda   +8 more
doaj   +1 more source

A Simulation Study on Multicomponent Lipid Bilayer

, 2005
Simulation of a multicomponent lipid bilayer having a fixed percentage of cholesterol is done to study phase transition leading to domain formation.
Anderson, Anderson, Banerjee, Banerjee, Ben-Shaul, Bloom, Brown, Brown, Brown, de Miguel, Doniach, Ermoshkin, Evans, Ferrenberg, Harrison, Jacobson, Jayashree Saha, Lee, May, Mouritsen, Nielsen, Nielsen, Radhakrishnan, Sabra, Scherfeld, Simons, Simons, Srilekha Banerjee, Zhang   +28 more
core   +1 more source

Sphingolipids and lifespan regulation [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
Diseases including cancer, type 2 diabetes, cardiovascular and immune dysfunction and neurodegeneration become more prevalent as we age, and combined with the increase in average human lifespan, place an ever increasing burden on the health care system.
Bradley R. Withers, Xinhe Huang, Robert C. Dickson   +2 more
openaire   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort. [PDF]

, 2019
Lipids play a role in many biological functions and the newly emerging field of lipidomics aims to characterize the varying classes of lipid molecules present in biological specimens.
Bradman, Asa, Eskenazi, Brenda, HOLLAND, Nina, Huen, Karen, Lee, Douglas, Tindula, Gwen   +5 more
core  

Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]

, 2016
In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
core   +2 more sources