Results 111 to 120 of about 14,105 (264)

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Solid-state NMR and x-ray diffraction investigations of sphingomyelin model membranes

, 2009
The only sphingolipid occurring naturally in mammalian cells, sphingomyelin (SM) is of great importance. Having predominantly long, saturated acyl chains it has an unusually high melting temperature (around physiological temperature) and has been ...
Shaw, Karen Paula, Shaw, Karen Paula
core   +1 more source

Lipidomic analysis of plasma samples from women with polycystic ovary syndrome [PDF]

, 2015
Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagnostic.
A Dunaif, AD Postle, B Banaszewska, B Matharoo-Ball, BC Choi, C Hughes, Catharine A. Ortori, Charlie Hodgman, Clare Daykin, David A. Barrett, Dov J. Stekel, J Friedman, JK Reddy, JY Kim, L Sun, M Insenser, M Luque-Ramirez, M Urbanek, MR Wenk, MS Bloom, NG Woods, Nick Raine-Fenning, O Quehenberger, PG Munder, PJ Meikle, R Kolesnick, R Pasquali, R Punnonen, RA Wild, Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, RS Legro, Srinivasarao Ravipati, W Atiomo, WA March, William Atiomo, WU Atiomo, X Han, X Ma, Y Zhao, Zeina Haoula, ZJ Chen   +40 more
core   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, EarlyView.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Utilizing Thiocholesterol As A Hydrophobic Probe To Characterize Lipid Phase Behaviour [PDF]

, 2017
Lipid seperti sfingomielin, gliserofosfolipik dan kolesterol merupakan komponen utama yang membentuk serta mengekalkan kestabilan dan dinamik membran plasma eukariotik Lipids, such as sphingomyelins, glycero-phospholipids and cholesterol, represent ...
Lee, Yan Fen
core  

Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex Vivo Skin

Contact Dermatitis, EarlyView.
This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy, Lina Hagvall, Per Malmberg, Niamh M. O'Boyle   +3 more
wiley   +1 more source

Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study

Frontiers in Neurology
BackgroundSphingolipids are implicated in neurodegeneration and neuroinflammation. We assessed the potential role of circulating ceramides and sphingomyelins in subclinical brain pathology by investigating their association with brain magnetic resonance ...
Kristine F. Moseholm, Jens W. Horn, Annette L. Fitzpatrick, Luc Djoussé, Luc Djoussé, W. T. Longstreth, W. T. Longstreth, Oscar L. Lopez, Andrew N. Hoofnagle, Majken K. Jensen, Majken K. Jensen, Rozenn N. Lemaitre, Kenneth J. Mukamal   +12 more
doaj   +1 more source

The lipid composition of the electric organ of the ray, Torpedo marmorata, with specific reference to sulfatides and Na+-K+-ATPase.

Journal of Lipid Research, 1979
The lipids from the electric organ of the ray, Torpedo marmorata, have been isolated and characterized. The major lipids were cholesterol, choline phospholipids, ethanolamine phospholipids, and sphingomyelins.
G C Hansson, E Heilbronn, K A Karlsson, B E Samuelsson   +3 more
doaj   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source