Results 101 to 110 of about 9,105 (228)

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Wooden‐Tip Electrospray Ionization Mass Spectrometry Combined With Machine Learning for Differentiating Thyroid Tumours

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Direct mass spectrometry (MS) analysis of human tissues at the molecular level has great potential for clinical diagnosis and biomarker discovery. However, conventional MS‐based analytical methods often require complicated and time‐consuming sample preparation, which limits their applicability in rapid clinical analysis.
Da‐Sheng Liu, Li Liu, Baixue Wang, Jianfeng Zhang, Hong‐Guo Lin, Xiang‐Xiong Huang, Kang‐Jian Deng, Yu‐Teng Zhou, Yunlong Pan, Bin Hu, Xue‐Yang Huang   +10 more
wiley   +1 more source

Discrimination of Lipid Hydroperoxide Positional Isomers Using SFC– MS/MS With Sodium Ion: Its Application to Evaluating the Oxidation Mechanisms of Oxidized Oils

Journal of the American Oil Chemists' Society, Volume 103, Issue 6, Page 623-632, June 2026.
ABSTRACT Advanced lipid profiling relies on liquid chromatography–tandem mass spectrometry (LC–MS/MS), but long analysis times remain a challenge. Supercritical fluid chromatography (SFC)–MS/MS using supercritical carbon dioxide offers a faster and more environmentally friendly alternative.
Ryosuke Aoki, Masayoshi Sakaino, Junya Ito, Shunji Kato, Jun Imagi, Toshiro Sato, Kiyotaka Nakagawa   +6 more
wiley   +1 more source

Sphingomyelin [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Our integrative Mendelian randomization framework revealed that specific circulating metabolites exert causal effects on major depressive disorder, partly through immune‐cell–mediated pathways. These findings highlight metabolite–immune interactions as potential mechanistic targets for MDD prevention and therapy.
Zhiwei Xu, Yining Zhou, Xuecheng Zhang, Xiaowen Chen, Yajing Li, Jintao Wang, Ting Chang, Zhen Yuan, Hongling Jia   +8 more
wiley   +1 more source

Genetic ancestry–concordant ceramide metabolism and response to androgen receptor pathway inhibition in metastatic castration‐resistant prostate cancer

Cancer, Volume 132, Issue 11, 1 June 2026.
Abstract Background The authors observed differences in response between Black and White patients with metastatic castration‐resistant prostate cancer (mCRPC) who were treated prospectively with androgen receptor pathway inhibition (ARPI) in the Abi Race and PANTHER studies.
Sean A. Piwarski, Lauren E. Howard, Morgan A. Paul, Nick Bachelder, Bonnie LaCroix, Angela Clayton, Donna Allen, Julie Kephart, Andrew J. Armstrong, Steven R. Patierno, Daniel J. George, Terry Hyslop, Jennifer A. Freedman   +12 more
wiley   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Studies on cerebral sphingomyelin [PDF]

Biochemical Journal, 1961
G B, ANSELL, S, SPANNER
openaire   +2 more sources

Current advances in liposome–extracellular vesicle hybrid systems for cancer drug delivery

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Liposome–extracellular vesicle hybrids combine synthetic stability with biological targeting capability. Hybrid nanovesicles enhance drug loading efficiency and tumour‐specific delivery. Advanced fusion strategies improve membrane integration and functional preservation.
Arina Habibi, Mohana Sakhti, Touraj Ahmadi Jouybari, Parnian Yavari, Reza Mozafari, Gelavizh Rostaminasab, Shima Rahmati   +6 more
wiley   +1 more source