Results 91 to 100 of about 14,105 (264)

ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin[S]

Journal of Lipid Research, 2013
ATP-binding cassette protein G1 (ABCG1) is important for the formation of HDL. However, the biochemical properties of ABCG1 have not been reported, and the mechanism of how ABCG1 is involved in HDL formation remains unclear. We established a procedure to
Hiroshi Hirayama, Yasuhisa Kimura, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda   +4 more
doaj   +1 more source

Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future [PDF]

, 2016
Metabolomics and lipidomics are emerging methods for detailed phenotyping of small molecules in samples. It is hoped that such data will: (i) enhance baseline prediction of patient response to pharmacotherapies (beneficial or adverse); (ii) reveal ...
Preiss, David, Rankin, Naomi J., Sattar, Naveed, Welsh, Paul   +3 more
core   +2 more sources

Particle simulation approach for subcellular dynamics and interactions of biological molecules [PDF]

, 2006
Background Spatio-temporal dynamics within cells can now be visualized at appropriate resolution, due to the advances in molecular imaging technologies. Even single-particle tracking (SPT) and single fluorophore video imaging (SFVI) are now being applied
Ryuzo Azuma, Tetsuji Kitagawa, Hiroshi Kobayashi, Akihiko Konagaya, F Daumas, K Ritchie, Y Shav-Tal, Y Shav-Tal, D Fusco, K Murase, A Kusumi, Y Barenholz, T Fujiwara, CW Gardiner, HA Kramers, M Arrio-Dupont, MV Smoluchouski, FC Collins, WK Subczynski, M Pasenkiewicz-Gierula, T Gil, MS Bretscher, A Kusumi, H Ike, AB Stundzia, J Elf, DT Gillespie, DT Gillespie, MB Elowitz, PS Swain, SJ Singer, Y Barenholz, A Veillette, A Leo   +33 more
core   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides

Journal of Lipid Research, 2000
Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique ω-hydroxylated Cer, that are key components of the stratum corneum (SC) intercellular lamellar membranes responsible for the epidermal permeability barrier ...
Yoshikazu Uchida, Mariko Hara, Hiroyuki Nishio, Ellen Sidransky, Shintaro Inoue, Fujio Otsuka, Akemi Suzuki, Peter M. Elias, Walter M. Holleran, Sumiko Hamanaka   +9 more
doaj   +1 more source

Cholesterol and nicotinic acetylcholine receptor: An intimate nanometer-scale spatial relationship spanning the billion year time-scale [PDF]

, 2016
Once the sterol biosynthetic machinery had progressed over the course of several million years to yield cholesterol, this neutral lipid became an omnipresent and essential component of biomembranes in Eukaryotes.
Barrantes, Francisco Jose
core   +1 more source

Interaction of ceramides with phosphatidylcholine, sphingomyelin and sphingomyelin/cholesterol bilayers

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2001
Ceramides (Cers) may exert their biological activity through changes in membrane structure and organization. To understand this mechanism, the effect of Cer on the biophysical properties of phosphatidylcholine, sphingomyelin (SM) and SM/cholesterol bilayers was determined using fluorescence probe techniques. The Cers were bovine brain Cer and synthetic
openaire   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography

Journal of Lipid Research, 2002
This study reports a single-step analysis of the molecular species of endogenous ceramides and of the ceramide moiety of sphingomyelins in biological samples, using gas liquid chromatography (GLC).
Claude Vieu, François Tercé, Françoise Chevy, Corinne Rolland, Ronald Barbaras, Hugues Chap, Claude Wolf, Bertrand Perret, Xavier Collet   +8 more
doaj   +1 more source