Results 71 to 80 of about 9,168 (223)

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides

Journal of Lipid Research, 2000
Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique ω-hydroxylated Cer, that are key components of the stratum corneum (SC) intercellular lamellar membranes responsible for the epidermal permeability barrier ...
Yoshikazu Uchida, Mariko Hara, Hiroyuki Nishio, Ellen Sidransky, Shintaro Inoue, Fujio Otsuka, Akemi Suzuki, Peter M. Elias, Walter M. Holleran, Sumiko Hamanaka   +9 more
doaj   +1 more source

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

iMeta, EarlyView.
Early‐pregnancy microbiome and lipidome profiling identified a microbiome‐glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, women who later developed GDM showed altered gut microbial composition, enriched microbial lipid biosynthesis pathways, and broad plasma lipidomic changes ...
Zhonghan Sun, Chang He, Xiaonan Ma, Ping Wu, Tianlei Wang, Jiaying Yuan, Yanni Pu, Xiaofeng Zhou, Zhendong Mei, Huiling Song, Yetong Wang, Haiyan Yue, Yuanqing Fu, Jusheng Zheng, An Pan, Da Chen, Shangyu Hong, Xiong‐Fei Pan, Yan Zheng   +18 more
wiley   +1 more source

Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography

Journal of Lipid Research, 2002
This study reports a single-step analysis of the molecular species of endogenous ceramides and of the ceramide moiety of sphingomyelins in biological samples, using gas liquid chromatography (GLC).
Claude Vieu, François Tercé, Françoise Chevy, Corinne Rolland, Ronald Barbaras, Hugues Chap, Claude Wolf, Bertrand Perret, Xavier Collet   +8 more
doaj   +1 more source

Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals

Scientific Reports, 2020
Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is ...
Melissa M. Ledet, Rebecca M. Harman, Jennifer C. Fan, Emily Schmitt-Matzen, Maria Elena Diaz-Rubio, Sheng Zhang, Gerlinde R. Van de Walle   +6 more
doaj   +1 more source

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

Journal of Biological Chemistry, 1994
Sphingomyelin (SM) is a membrane phosphosphingolipid that has recently been identified as a key component of the SM cycle. In this signal transduction pathway, extracellular inducers such as tumor necrosis factor alpha cause hydrolysis of membrane SM, resulting in the generation of the lipid second messenger ceramide. Only 10-20% of cellular SM appears
C M, Linardic, Y A, Hannun
openaire   +2 more sources

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, EarlyView.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Research Advances in Regulatory Effect of Phospholipids on Meat Quality [PDF]

Shipin Kexue
Phospholipids, a class of polar lipids with complex structure and multiple functions, are composed of glycerophospholipids and sphingomyelins. As an important component of cell membranes, phospholipids are involved in many physiological activities, such ...
ZHANG Kaihua, ZANG Mingwu, Wang Shouwei, ZHANG Zheqi, LI Dan, LI Xiaoman, HAO Rui
doaj   +1 more source

Comparison of methods for defatted human milk and nutrient composition: An experimental study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Human milk is considered the gold standard for infant nutrition; however, it is often discontinued in chylothorax and severe very long‐chain acyl‐CoA dehydrogenase (VLCAD) deficiency. As an alternative to complete human milk restriction, defatted human milk may be fed, though it may not fully support optimal infant growth and ...
Kristin Cheng, Gina O'Toole, Stephanie Chang, Richard Chang, John Miklavcic   +4 more
wiley   +1 more source

Low serum sphingolipids in children with attention deficit-hyperactivity disorder

Frontiers in Neuroscience, 2015
Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Marcela Patricia Henríquez-Henríquez, Marcela Patricia Henríquez-Henríquez, Sandra eSolari, Teresa eQuiroga, Benjamin I Kim, Richard J. Deckelbaum, Tilla S. Worgall   +6 more
doaj   +1 more source