Results 61 to 70 of about 11,288 (198)

Partial synthesis and properties of a series of N-acyl sphingomyelins.

Journal of Lipid Research, 1987
A series of sphingomyelins (SM) with different chain length fatty acids (C14:0, C16:0, C18:0, C20:0, C22:0, and C24:0) N-linked to the primary amino group of sphingosine have been synthesized starting with bovine brain SM.
P K Sripada, P R Maulik, J A Hamilton, G G Shipley   +3 more
doaj   +1 more source

Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China.

PLoS Medicine, 2020
BackgroundAnimal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited.
Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin   +9 more
doaj   +1 more source

The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age.

PLoS ONE, 2017
Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French
Séverine Trabado, Abdallah Al-Salameh, Vincent Croixmarie, Perrine Masson, Emmanuelle Corruble, Bruno Fève, Romain Colle, Laurent Ripoll, Bernard Walther, Claire Boursier-Neyret, Erwan Werner, Laurent Becquemont, Philippe Chanson   +12 more
doaj   +1 more source

Visualizing sphingomyelin in the retina

Experimental Eye Research
Sphingomyelin (SM) is a major component of cellular membranes that is altered by retinal and optic nerve degenerations. However, our understanding of the influence of SM during degenerations is hampered by methodological limitations. Prior investigations have demonstrated the accumulation of SM to plasma membranes of cultured cells, using an enhanced ...
Cassandra Warden, Dalton Raymond, Alex Sanchez, Mathew Seidel, Michael L. Risner   +4 more
openaire   +2 more sources

Distribution of molecular species of sphingomyelins in different parts of bovine digestive tract

Journal of Lipid Research, 1975
Sphingomyelins were isolated from mucosal layers of bovine rennet stomach, duodenum, jejunoileum, and colon ascendens. The ceramides obtained after phospholipase degradation were characterized by thin-layer chromatography, mass spectrometry, and gas ...
M.E. Breimer
doaj   +1 more source

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis.

, 2012
BACKGROUNDCurrent non-invasive diagnostic methods for endometriosis lack sensitivity and specificity. In search for new diagnostic biomarkers for ovarian endometriosis, we used a hypothesis-generating targeted metabolomics approach.METHODSIn a case ...
Prehn, C., Rizner, T.L., Osredkar, J., Adamski, J., Hevir, N., Ribič-Pucelj, M., Vouk, K., Haarpaintner, G., Scherb, H., Möller, G.   +9 more
core   +1 more source

Rank of the changed mean mass levels of individual sphingomyelin and ceramide molecular species in all AD patients relative to the normal controls (panel A) and the differences in sphingomyelins and ceramides between patients with moderate Alzheimer's disease (MMSE<20) and patients with mild Alzheimer's disease (MMSE> = 20) (panel B).

, 2013
The Y axes show the standardized differences in lipid level: lipid levels were standardized to a mean of 0 and standard deviation of 1 across all samples before ranking and plotting.
Stephen H. Boyle (348270), Hua Cheng (317084), Rima Kaddurah-Daouk (152187), P. Murali Doraiswamy (35724), Kathleen A. Welsh-Bohmer (258166), Xianlin Han (83121), James R. Burke (258157), Steve Rozen (134498), Caroline Hellegers (35723)   +8 more
core   +1 more source

Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses

Many flaviviruses with high pandemic potential are transmitted through mosquito bites. While mosquito saliva is essential for transmission and represents a promising pan-flaviviral target, there is a dearth of knowledge on salivary metabolic transmission
Tavadia, Mihra, Infectious Diseases and Immunology - Infection Biology, Revel, Justine, Nolte-'t Hoen, Esther, Missé, Dorothée, Miot, Elliott F, Pompon, Julien, Hitakarun, Atitaya, Medkour, Hacène, Pruvost, Lauryne, Sornjai, Wannapa, Nisole, Sébastien, Duncan Smith, R, Bertrand-Michel, Justine, Gong, Xiaoqian, Vaissayre, Virginie, Boutinaud, Pascal, Marti, Guillaume, Infectiebiologie, Zoladek, Jim   +19 more
core   +2 more sources

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Journal of Translational Medicine, 2019
Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute ...
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler   +21 more
doaj   +1 more source

Membrane bilayer properties of sphingomyelins with amide-linked 2- or 3-hydroxylated fatty acids [PDF]

, 2011
The bilayer properties and interactions with cholesterol of N-acyl hydroxylated sphingomyelins (SM) were examined, and results were compared to nonhydroxylated chain-matched SM.
Slotte, J. Peter, Ekholm, Oscar, Jaikishan, Shishir, Lönnfors, Max, Shishir Jaikishan, Max Lönnfors, Thomas K.M. Nyholm, Nyholm, Thomas K.M., Oscar Ekholm, J. Peter Slotte   +9 more
core   +1 more source