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Sphingosine 1-phosphate: synthesis and release
Prostaglandins & Other Lipid Mediators, 2001Sphingosine 1-phosphate (Sph-1-P) is a bioactive sphingolipid, acting both as an intracellular second messenger and extracellular mediator, in mammalian cells. In cell types where Sph-1-P acts as an intracellular messenger, stimulation-dependent synthesis of Sph-1-P, possibly resulting from sphingosine (Sph) kinase activation, is essential.
Y, Yatomi +3 more
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Pleiotropic actions of sphingosine-1-phosphate
Progress in Lipid Research, 2003Sphingosine-1-phosphate (SIP) is a bioactive sphingolipid metabolite that regulates diverse cellular responses including, growth, survival, cytoskeleton rearrangements and movement. SIP plays an important role during development, particularly in vascular maturation and has been implicated in pathophysiology of cancer, wound healing, and atherosclerosis.
Kenneth, Watterson +3 more
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Sphingosine 1-phosphate signalling in cancer
Biochemical Society Transactions, 2012There is an increasing body of evidence demonstrating a critical role for the bioactive lipid S1P (sphingosine 1-phosphate) in cancer. S1P is synthesized and metabolized by a number of enzymes, including sphingosine kinase, S1P lyase and S1P phosphatases. S1P binds to cell-surface G-protein-coupled receptors (S1P1–S1P5) to elicit cell responses and can
Nigel J, Pyne +5 more
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Sphingosine-1-phosphate and lipid phosphohydrolases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts as both an extracellular ligand for the endothelial differentiation gene-1 (EDG-1) G-protein coupled receptor (GPCR) family and as an intracellular messenger. Cellular levels of S1P are low and tightly regulated in a spatial-temporal manner not only by sphingosine kinase (SPHK) but ...
Hervé, Le Stunff +4 more
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Sphingosine-1-Phosphate Signaling and the Skin
American Journal of Clinical Dermatology, 2007Sphingolipids have long been viewed as rather passive structural components of cellular membranes. More recently, it has become evident that metabolism of sphingomyelin yields several lipid mediators that evoke diverse and specific responses in different cell types.
Thomas, Herzinger +3 more
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Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19
EMBO Molecular Medicine, 2021Giovanni Marfia +2 more
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