Results 91 to 100 of about 75,057 (290)

Flow dynamics control the effect of sphingosine-1-phosphate on endothelial permeability in a microfluidic vessel bifurcation model [PDF]

, 2018
Blood vessels are lined by endothelial cells that form a semipermeable barrier to restrict fluid flow across the vessel wall. The endothelial barrier is known to respond to various molecular mechanisms, but the effects of mechanical signals that arise ...
Spychalski, Griffin
core  

The emerging role of FTY720 (Fingolimod) in cancer treatment [PDF]

, 2016
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor.
Abdollahi, Alewijnse, Alexander, Aradhye, Arai, Arlinghaus, Bae, Baumruker, Baxter, Ben-Sasson, Bohler, Bollen, Braun, Brinkmann, Broek, Brune, Brune, Bueno, Bueno, Bueno, Burtin, Byrd, Cabot, Campochiaro, Chauhan, Chen, Chiba, Curino, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cyster, Cyster, Edwards, Eshhar, Fan, Fan, Fan, Fan, Ferrer, Gajewski, Garcia, Garcia-Foncillas, Garcia-Foncillas, Geilen, Grech, Greten, Habib, Hahn, Hakomori, Hakomori, Hakomori, Han, Han, Hanessian, Hannun, Hannun, He, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hoshino, Huang, Huwiler, Huwiler, Huwiler, Huyton, Ibrahim, Igarashi, Igarashi, Igarashi, Jaffrezou, Kappos, Karliner, Karliner, Kasahara, Katsuoka, Katsuoka, Katsuoka, Kaufmann, Klostergaard, Kohama, Kordula, Kornblau, Lee, Lee, Lei, Lei, Li, Liao, Lichter, Liu, Liu, Liu, Lynch, Lynch, Lynch, Macdonald, Marcucci, Masood, Matsuyama, May, May, Moolenaar, Morisaki, Mosser, Muthusamy, Muthusamy, Muthusamy, Nakamura, Neviani, Neviani, Nozawa, Nozawa, Nussbaumer, Obeid, Obeid, Obeid, Obeid, Oberlies, Odero, Ogretmen, Ohdan, Okumoto, Okuyama, Park, Pchejetski, Pchejetski, Phelps, Pitson, Pitson, Pitson, Pollard, Prior, Proia, Proia, Pyne, Pyne, Pyne, Pyne, Pyne, Pyne, Rader, Radue, Rennard, Rodrigues, Rosen, Rosen, Roy, Ruefli-Brasse, Sabbadini, Sakaguchi, Sanchez, Satoh, Schmouder, Schwartz, Seishima, Sharma, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Smith, Smith, Song, Song, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Stracke, Stracke, Stracke, Sun, Suzuki, Suzuki, Tagliaferri, Tagliaferri, Takahara, Takuwa, Takuwa, Taniwaki, Tornquist, Troncone, Uesato, Vadas, Vadas, Vadas, Vadas, Verrills, Walsh, Wang, Wang, Wattenberg, Wattenberg, Waxman, Weichselbaum, Wiedermann, Wolf, Wong, Wong, Wood, Woodcock, Wu, Xia, Xia, Xia, Xia, Xu, Xu, Yap, Yee, Yun, Yun, Zangemeister-Wittke, Zawadzke, Zheng, Zheng   +249 more
core   +2 more sources

Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury

Arthritis & Rheumatology, 2018
Immune complex (IC) deposition activates polymorphonuclear neutrophils (PMNs), increases vascular permeability, and leads to organ damage in systemic lupus erythematosus and rheumatoid arthritis.
N. Burg, S. Swendeman, S. Worgall, T. Hla, J. Salmon   +4 more
semanticscholar   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

Journal of Lipid Research, 2016
Based on research carried out over the last decade, it has become increasingly evident that bile acids act not only as detergents, but also as important signaling molecules that exert various biological effects via activation of specific nuclear ...
Masayuki Nagahashi, Kizuki Yuza, Yuki Hirose, Masato Nakajima, Rajesh Ramanathan, Nitai C. Hait, Phillip B. Hylemon, Huiping Zhou, Kazuaki Takabe, Toshifumi Wakai   +9 more
doaj   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Scientific Reports, 2021
Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are controversial ...
Haonan Liu, Molly L. Jackson, Lucy J. Goudswaard, Samantha F. Moore, James L. Hutchinson, Ingeborg Hers   +5 more
doaj   +1 more source

Sphingosine 1-phosphate receptor 1 is required for MMP-2 function in bone marrow mesenchymal stromal cells: implications for cytoskeleton assembly and proliferation [PDF]

, 2018
Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling
Anderloni, Giulia, Chellini, Flaminia, Frati, Alessia, Matteini, Francesca, Meacci, Elisabetta, Nosi, Daniele, Pierucci, Federica, Sassoli, Chiara, Tani, Alessia, Vestri, Ambra, Zecchi-Orlandini, Sandra   +10 more
core   +4 more sources

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source