Results 111 to 120 of about 29,328 (213)

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Sphingosine 1-phosphate receptor [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies

Scientific Reports
Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health.
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara   +11 more
doaj   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, Volume 7, Issue 4, August 2026.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Bridging the Pregnancy Knowledge Gap: A Real‐World Analysis of Medication Use and Drug–Drug Interaction Risk in Crohn's Disease and Multiple Sclerosis

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The exclusion of pregnant individuals from clinical trials has resulted in a significant medical knowledge gap for this population. Leveraging real‐world data (RWD) provides a critical window into the prevalence and use of medications during pregnancy.
Jacqueline Williams, Rucha Sane, Amita Joshi, Kit Wun Kathy Cheung, Bianca Vora   +4 more
wiley   +1 more source

The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Partial hepatectomy (PH) reshapes gut microbiota composition, resulting in the release of microbial metabolites and components, including short chain fatty acids (SCFAs)/β‐hydroxybutyric acid (BHB), bacterial DNA and extracellular vesicles (EVs), bile acids (deoxycholic acid, DCA), and aminobenzoate degradation products.
Roberto Loi, Gabriella Simbula, Andrea Caddeo, Monica Pibiri   +3 more
wiley   +1 more source

Pan-cancer signaling landscape linked to endothelial and immune Sphingosine-1-phosphate receptor 1 (S1PR1) expression. [PDF]

In Silico Pharmacol
Torres-Santos Y, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J.   +3 more
europepmc   +1 more source

Imaging Sphingosine-1-Phosphate Receptor: A Promising Strategy to Neuroinflammation of Epilepsy. [PDF]

Mol Imaging
Xu S, Yu Y, Brier MR, Benzinger TLS, Tu Z.   +4 more
europepmc   +1 more source

Expression of sphingosine-1-phosphate receptor 1 in the brain of fatal cerebral malaria. [PDF]

Sci Rep
Srisook C, Nintasen R, Punsawad C, Glaharn S, Techarang T, Viriyavejakul P.   +5 more
europepmc   +1 more source

Sphingosine-1-Phosphate Receptor 5 Signaling Is Redundant in Preclinical Models of Inflammatory Bowel Disease. [PDF]

Cell Mol Gastroenterol Hepatol
Łukasik Z, Coudenys J, Jarlborg M, Venken K, Hochepied T, Gilis E, Elewaut D.   +6 more
europepmc   +1 more source