Results 131 to 140 of about 31,038,441 (242)

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Sphingosine 1-Phosphate Induces Platelet/Endothelial Cell Adhesion Molecule-1 Phosphorylation in Human Endothelial Cells through Csrc and Fyn

, 2009
Sphingosine 1-phosphate (S1P) is a multifunctional phospholipid which acts through a specific family of G protein-coupled receptors. Platelet/ endothelial cell adhesion molecule-1 (PECAM-1) form trans-homophilic binding at lateral cell border.
HUANG, YU-TING;CHEN, SHEE-UAN;CHOU, CHIA-HUNG;LEE, HSIN-YU, 黃鈺婷;陳思原;周佳宏;李心予   +1 more
core   +1 more source

Life‐History, Stress‐Resistance, and Transcriptomic Variation Among a Mexican Caenorhabditis elegans Isolate and Contemporary and Ancestral N2 Lineages

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared a recently isolated wild strain of Caenorhabditis elegans from Mexico City (VJV2) with the contemporary standard N2 Lab strain and the cryopreserved N2 Ancestral lineage. The strains differed in lifespan, fertility, and survival under pathogen, oxidative, and heat stress.
Jaqueline Hersch‐González, Nallely Cano‐Domínguez, Mariana Zurita‐León, Francisco Pinta‐Castro, Maribel Soto‐Nava, Santiago Avila‐Rios, Victor Julian Valdes   +6 more
wiley   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Sphingosine 1-phosphate receptor gene, SPPR

, 2011
A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune ...
Kothapalli, Ravi, Loughran, Thomas P.
core  

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment

Biology of the Cell, Volume 118, Issue 10, October 2026.
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier, Apolline Salama, Laurence Dubreil, Grégoire Mignot, Steffi Bosch   +4 more
wiley   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1626-1647, October 2026.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

Journal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source