Results 11 to 20 of about 75,057 (290)

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2* [PDF]

Journal of Lipid Research, 2009
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in ...
Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi   +14 more
doaj   +3 more sources

Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery [PDF]

Biomolecules & Therapeutics, 2017
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, S1P1–5.
Soojin Park, D. Im
semanticscholar   +3 more sources

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +3 more sources

Sphingosine-1-phosphate receptor 2 [PDF]

FEBS Journal, 2013
Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs).
Mohamad, Adada, Daniel, Canals, Yusuf A, Hannun, Lina M, Obeid   +3 more
openaire   +2 more sources

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

ESC Heart Failure, 2023
Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau   +16 more
doaj   +1 more source

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Multiple sclerosis is a disease of the central nervous system with an autoimmune and neurodegenerative component. While numerous drugs are available to ameliorate autoimmunity, just some drugs so far have demonstrated effects suggestive of ...
N. Behrangi, Leo Heinig, Linda Frintrop, Emily Santrau, J. Kurth, Bernd J. Krause, D. Atanasova, T. Clarner, A. Fragoulis, M. Joksch, Henrik Rudolf, S. Meuth, Sarah Joost, M. Kipp   +13 more
semanticscholar   +1 more source

Sphingosine‐1‐phosphate receptor 3 is implicated in BBB injury via the CCL2‐CCR2 axis following acute intracerebral hemorrhage

CNS Neuroscience & Therapeutics, 2021
Intracerebral hemorrhage (ICH) is a catastrophic cerebrovascular disease with high morbidity and mortality. Evidence demonstrated that sphingosine‐1‐phosphate receptor (S1PR) plays a vital role in inflammatory damage via the upregulation of CCL2 ...
Di Xu, Qiang Gao, Fang Wang, Qianrui Peng, Guoqing Wang, Qingjie Wei, Shixiong Lei, Shengqi Zhao, Longxiao Zhang, Fuyou Guo   +9 more
semanticscholar   +1 more source

Review article: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis ‐ a unique therapeutic target in inflammatory bowel disease

Alimentary Pharmacology and Therapeutics, 2021
Ozanimod, a high selective sphingosine 1 phosphate (S1P) receptor (S1PR) 1/5 modulator was approved by the Food and Drug Administration for the treatment of adult patients with moderately to severely active ulcerative colitis.
Jie Wang, I. Goren, Bo Yang, Si-nan Lin, Jiannan Li, M. Elias, C. Fiocchi, F. Rieder   +7 more
semanticscholar   +1 more source

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases

Biomolecules, 2023
Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3 ...
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen   +3 more
doaj   +1 more source

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. [PDF]

PLoS ONE, 2013
OBJECTIVE: Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source