Results 21 to 30 of about 75,057 (290)

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects

Drugs, 2020
Lysophospholipids are a class of bioactive lipid molecules that produce their effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps the most studied lysophospholipid and has a role in a wide range of ...
J. Chun, G. Giovannoni, S. Hunter
semanticscholar   +1 more source

Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations

HYPERTENSION, 2021
Supplemental Digital Content is available in the text. Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia ...
Jiujiang Liao, Yangxi Zheng, Mingyu Hu, P. Xu, Li Lin, Xiyao Liu, Yue Wu, Biao Huang, Xuan Ye, Sisi Li, Ran Duan, Huijia Fu, Jiayu Huang, Li Wen, Yong Fu, M. Kilby, L. Kenny, P. Baker, H. Qi, Chao Tong   +19 more
semanticscholar   +1 more source

Does Siponimod Exert Direct Effects in the Central Nervous System?

Cells, 2020
The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes.
Markus Kipp
doaj   +1 more source

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Alemany, Alewijnse, Alexander, Ancellin, Blazquez, Chun, Coussin, Felder, French, Galve-Roperh, Giuliano, Grainger, Hajrasouliha, Hemmings, Hemmings, Herradon, Ho, Ho, Howlett, Igarashi, Igarashi, Ikeda, Jarai, Kobayashi, Long, Melendez, Mukhopadhyay, Mulvany, Nofer, O'Sullivan, Offertaler, Oka, Paugh, Peters, Pitson, Pratt, Pyne, Pyne, Romano, Roviezzo, Sanchez, Sarkar, Smart, Sukocheva, Taha, Venkataraman, White, Zygmunt   +47 more
core   +2 more sources

Targeting Sphingosine-1-Phosphate Receptors in Cancer [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2011
Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-protein-coupled receptors of the sphingosine-1-phosphate receptor family (S1PR) which play a crucial role ...
Rebecca J, Watters, Hong-Gang, Wang, Shen-Shu, Sung, Thomas P, Loughran, Xin, Liu   +4 more
openaire   +2 more sources

Structural determinants of sphingosine‐1‐phosphate receptor selectivity

Archiv der Pharmazie, 2023
AbstractFingolimod, the prodrug of fingolimod‐1‐phosphate (F1P), was the first sphingosine‐1‐phosphate receptor (S1PR) modulator approved for multiple sclerosis. F1P unselectively targets all five S1PR subtypes. While agonism (functional antagonism via receptor internalization) at S1PR1 leads to the desired immune modulatory effects, agonism at S1PR3 ...
Friederike Wunsch, Trung Ngoc Nguyen, Gerhard Wolber, Marcel Bermudez   +3 more
openaire   +3 more sources

Bile acids as global regulators of hepatic nutrient metabolism

Liver Research, 2017
Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon, Kazuaki Takabe, Mikhail Dozmorov, Masayuki Nagahashi, Huiping Zhou   +4 more
doaj   +1 more source

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives

Cells, 2020
Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu, Robert Brunkhorst, Josef M. Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu   +4 more
doaj   +1 more source

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Stem Cell Research & Therapy, 2022
Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still ...
Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant   +17 more
doaj   +1 more source

Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. [PDF]

, 2015
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process ...
Bui, Connor, De Tomaso, Anthony W, Kassmer, Susannah H, Langenbacher, Adam D, Rodriguez, Delany   +4 more
core   +1 more source