Results 171 to 180 of about 29,323 (206)
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Neurology, 2011
Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven +2 more
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Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven +2 more
openaire +2 more sources
Sphingosine 1-phosphate receptors
Prostaglandins & Other Lipid Mediators, 2001Sphingosine-1-phosphate (SPP) is a bioactive lipid produced from the metabolism of sphingomyelin. It is an important constituent of serum and regulates cell growth, survival, migration, differentiation and gene expression. Its mode of action has been enigmatic; however, recent findings have shown that a family of G-protein-coupled receptors (GPCR) of ...
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2022
Sphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P1, S1P2, S1P3, S1P4, S1P5, widely expressed in different cells, tissues and organs. In the cardiovascular system these receptors have been extensively studied, but no drug acting on them has been approved so far for treating cardiovascular diseases. In
Spampinato, Simona Federica +2 more
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Sphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P1, S1P2, S1P3, S1P4, S1P5, widely expressed in different cells, tissues and organs. In the cardiovascular system these receptors have been extensively studied, but no drug acting on them has been approved so far for treating cardiovascular diseases. In
Spampinato, Simona Federica +2 more
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Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis
CNS Drugs, 2021Fingolimod (Gilenya) received regulatory approval from the US FDA in 2010 as the first-in-class sphingosine 1-phosphate (S1P) receptor (S1PR) modulator and was the first oral disease-modifying therapy (DMT) used for the treatment of the relapsing forms of multiple sclerosis (MS).
Reshmi Roy +2 more
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European Journal of Pharmacology, 2001
Recently, a family of G-protein-coupled receptors named endothelial differentiation gene (Edg) receptor family has been identified, which are specifically activated by the two serum lipids, sphingosine-1-phosphate and lysophosphatidic acid. Sphingosine-1-phosphate can also act intracellularly to release Ca2+ from intracellular stores.
D, Meyer zu Heringdorf +6 more
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Recently, a family of G-protein-coupled receptors named endothelial differentiation gene (Edg) receptor family has been identified, which are specifically activated by the two serum lipids, sphingosine-1-phosphate and lysophosphatidic acid. Sphingosine-1-phosphate can also act intracellularly to release Ca2+ from intracellular stores.
D, Meyer zu Heringdorf +6 more
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Acta Haematologica, 2015
<b><i>Background/Aims:</i></b> This study investigated the priming effect of sphingosine 1-phosphate (S1P) on formyl-Met-Leu-Phe-OH (fMLP)-activated neutrophils, by specific analysis of the neutrophil respiratory burst and the signaling pathway involved in S1P activity.
Zhongying, Wang +6 more
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<b><i>Background/Aims:</i></b> This study investigated the priming effect of sphingosine 1-phosphate (S1P) on formyl-Met-Leu-Phe-OH (fMLP)-activated neutrophils, by specific analysis of the neutrophil respiratory burst and the signaling pathway involved in S1P activity.
Zhongying, Wang +6 more
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Mechanisms of sphingosine 1-phosphate receptor signalling in cancer
Cellular Signalling, 2017S1P is a small bioactive lipid which exerts its effects following binding to a family of five G protein-coupled receptors, known as S1P1-5. Following receptor activation, multiple signalling cascades are activated, allowing S1P to regulate a range of cellular processes, such as proliferation, apoptosis, migration and angiogenesis.
Sathya Narayanan Patmanathan +4 more
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[Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface.
Xin-pin, Zhuang, Qing, Zhu
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