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Molecular mechanisms of regulation of sphingosine kinase 1.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2018
Michael J. Pulkoski-Gross, L. Obeid
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[Sphingosine kinase-1 regulates migration and invasion of gastric cancer cells via targeting the nuclear factor-κB signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Ling Q, Ji K, Chen J, Guan J, Wang R, Man W, Zhu B.   +6 more
europepmc   +1 more source

Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. [PDF]

Biosci Rep
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Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

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Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway

Immunopharmacology and immunotoxicology, 2021
Objectives Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with high sphingosine kinase 1(SPHK1) expression in the colon, however its role in pathogenesis of UC is not clearly understood so, the aim of the present study
N. El-Mahdy, M. El-Sayad, A. H. El-Kadem, Sally E. Abu-Risha   +3 more
semanticscholar   +1 more source

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Michael, Maceyka, Shawn G, Payne, Sheldon, Milstien, Sarah, Spiegel   +3 more
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Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
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Sphingosine kinase 1 in viral infections

Reviews in Medical Virology, 2012
SUMMARYSphingosine kinase 1 (SphK1) is an enzyme that phosphorylates the lipid sphingosine to generate sphingosine‐1‐phosphate (S1P). S1P can act intracellularly as a signaling molecule and extracellularly as a receptor ligand. The SphK1/S1P axis has well‐described roles in cell signaling, the cell death/survival decision, the production of a pro ...
Carr, J., Mahalingam, S., Bonder, C., Pitson, S.   +3 more
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Targeting sphingosine kinase 1 in cancer

Advances in Biological Regulation, 2012
Cancer is one of largest killers in the world and defeating it represents one of the most important challenges in Medicine today. For instance, annually, around 1.38 million women are diagnosed worldwide with breast cancer and approximately 0.25 million men worldwide are diagnosed with prostate and testicular cancer.
Pyne, Nigel J, Tonelli, Francesca, Lim, Keng Gat, Long, Jaclyn, Edwards, Joanne, Pyne, Susan   +5 more
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