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Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway
2013Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
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Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system
Cellular Signalling, 2009Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells.
Taro, Okada +3 more
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Discovery of novel sphingosine kinase 1 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2009Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine (1), the substrate of this enzyme.
Yibin, Xiang +7 more
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2012
Sphingolipids (ceramide, sphingosine, and sphingosine-1-phosphate) are bioactive lipids with important biological functions in proliferation, apoptosis, angiogenesis, and inflammation. Herein, we describe easy and rapid biochemical methods with the use of radiolabeled molecules ((3)H, (32)P) for their mass determination.
Leyre, Brizuela, Olivier, Cuvillier
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Sphingolipids (ceramide, sphingosine, and sphingosine-1-phosphate) are bioactive lipids with important biological functions in proliferation, apoptosis, angiogenesis, and inflammation. Herein, we describe easy and rapid biochemical methods with the use of radiolabeled molecules ((3)H, (32)P) for their mass determination.
Leyre, Brizuela, Olivier, Cuvillier
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Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
Journal of Cellular Biochemistry, 2018Sphingosine kinases (SphKs) and ceramide kinase (CerK) phosphorylate sphingosine to sphingosine‐1‐phosphate (S1P) and ceramide to ceramide‐1‐phosphate (C1P), respectively. S1P and C1P are bioactive lipids that regulate cell fate/function and human health/
Shohei Nishino +6 more
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Activation of Sphingosine Kinase 1
2006Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that regulates many important biological processes as a ligand for cell surface receptors and as an intracellular second messenger. S1P levels inside cells are regulated in a temporal and spatial manner by the balance between its formation, catalyzed by two sphingosine kinase isoenzymes, SphK1 ...
Michael Maceyka +3 more
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Sphingosine 1-Phosphate and Sphingosine Kinase Activity during Chicken Embryonic Development
Archives of Pharmacal Research, 2007The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC
Chang-Hwan, Choi +8 more
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Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2
Bioorganic & Medicinal Chemistry Letters, 2004Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD ...
Peter, Ettmayer +5 more
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Stopping Sepsis by Targeting Sphingosine Kinase 1
Science Translational Medicine, 2010A recent study suggests that inhibiting the enzyme sphingosine kinase 1 might have great potential as a therapy for sepsis.
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