Results 241 to 250 of about 371,184 (271)

Building a better sphingosine kinase-1 inhibitor

Biochemical Journal, 2012
Sphingosine 1-phosphate (S1P) is currently one of the most intensely studied lipid mediators. Interest in S1P has been propelled by the development of fingolimod, an S1P receptor agonist prodrug, which revealed both a theretofore unsuspected role of S1P in lymphocyte trafficking and that such modulation of the immune system achieves therapeutic benefit
openaire   +2 more sources

Downregulating sphingosine kinase-1 for cancer therapy

Expert Opinion on Therapeutic Targets, 2008
The sphingolipids ceramide and sphingosine 1-phosphate (S1P) are key regulators of cell death and proliferation. The subtle balance between their intracellular levels is governed mainly by sphingosine kinase-1, which produces the pro-survival S1P. Sphingosine kinase-1 is an oncogene; is overexpressed in many tumors; protects cancer cells from apoptosis
openaire   +2 more sources

[Sphingosine kinase 1 and tumor].

Yao xue xue bao = Acta pharmaceutica Sinica, 2016
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) promotes cell survival and proliferation.
Cai-Xia, Zhang, Hong-Wei, He, Rong-Guang, Shao   +2 more
openaire   +1 more source

Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2020
Preeti Gupta, Faez Iqbal Khan, Sonam Roy, Saleha Anwar, Rashmi Dahiya, M. Alajmi, A. Hussain, M. Rehman, Dakun Lai, M. Hassan   +9 more
semanticscholar   +1 more source

Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis.

Life Science, 2020
Ming-Hui Sun, Ran Deng, Yan Wang, Hong Wu, Zhengrong Zhang, Yan-Hong Bu, Heng Zhang   +6 more
semanticscholar   +1 more source

The sphingosine kinase‐1/sphingosine‐1‐phosphate axis in cancer: Potential target for anticancer therapy

Pharmacology and Therapeutics, 2019
Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-yi Liu, Xiaocong Pang, Xiuping Chen, De Kang, Jinhua Wang, Guanhua Du   +8 more
semanticscholar   +1 more source

Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease

Nature Reviews Gastroenterology and Hepatology, 2022
Bram Verstockt, Stefania Vetrano, Azucena Salas   +2 more
exaly  

Sphingosine 1‐Phosphate Liposomes for Targeted Nitric Oxide Delivery to Mediate Anticancer Effects against Brain Glioma Tumors

Advanced Materials, 2021
Fang Yang
exaly  

LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway.

European Review for Medical and Pharmacological Sciences, 2018
Lei Liu, Zhou Xy, Zhang Jq, Wang Gg, J. He, Chen Yy, Chuanzhen Huang, Liang Li, Li Sq   +8 more
semanticscholar   +1 more source

Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases

Nature Reviews Rheumatology, 2022
Nathalie Burg, Timothy T Hla
exaly