Results 91 to 100 of about 5,876 (263)

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

Insect Molecular Biology, EarlyView.
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork, Sihang Xu, Athula Attygalle, Tanya Renner   +3 more
wiley   +1 more source

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]

, 2014
© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman, Aird, Alarcon-Chaidez, Altschul, Alves-Silva, Ambrose, Anatriello, Anderluh, Bakrac, Bakrac, Balasubramanian, Barlic, Binford, Binford, Björn M. von Reumont, Bon, Borda, Bradnam, Brinkman, Böggemann, Casewell, Castaneda, Castaneda, Chagas, Chang, Chen, Christoph Bleidorn, Conesa, Conesa, Cuypers, Dan Sykes, Darriba, De Colibus, Earl, Eddy, Fauchald, Favreau, Fernandes-Pedrosa, Francischetti, Fry, Fry, Garb, Garcia, Garcia-Ortega, Ghadessy, Giese, Giray, Grabherr, Hargreaves, He, Honma, Jungo, Jörg Hetmank, Kagan, Katoh, Kawashima, Khalturin, King, King, Kircher, Kiriake, Klawe, Kobayashi, Koua, Krebs, Kristan, Kvist, Lahcen I. Campbell, Lars Hering, Lin, Low, Low, Manaranche, Mancheno, Margres, Martin, Meunier, Meunier, Meyer, Michel, Michel, Min, Morgenstern, Morgenstern, Moses, Nakamura, Olivera, O’Neil, Peng, Pennington, Petersen, Rangaraju, Rigoni, Rokyta, Ronald A. Jenner, Rosenberg, Rouse, Safavi-Hemami, Sandy Richter, Schenning, Shiomi, Shiomi, Smeds, Stamatakis, Sukumwang, Sunagar, Terrat, Ueda, Ungerer, Violette, von Reumont, Vonk, Warren, Watala, Weston, Whittington, Wong, Zdobnov, Zhang, Zimmerberg, Zobel-Thropp   +120 more
core   +1 more source

Sphingomyelinase D from loxosceles laeta venom induces the expression of MMP7 in human keratinocytes: contribution to dermonecrosis [PDF]

, 2016
Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Correa, Mara A., Goncalves-de-Andrade, Rute M., Okamoto, Cinthya K., Tambourgi, Denise V., van den Berg, Carmen W.   +4 more
core   +3 more sources

Making with the Trouble: Un/Enfolding Posthuman Participants with Young People in Creative Post‐Qualitative Research

International Journal of Art &Design Education, EarlyView.
Abstract This paper explores how ‘what matters’ can surface in multisensory arts‐informed projects as ways for young people to survive and stay with gender and sexuality troubles that are always more than theirs. Situated in an ex‐mining post‐industrial locale, we make an agential cut in a longitudinal research and engagement project called Unboxing ...
EJ Renold
wiley   +1 more source

Transcriptome and venom proteome of the box jellyfish Chironex fleckeri [PDF]

, 2015
Background: The box jellyfish, Chironex fleckeri, is the largest and most dangerous cubozoan jellyfish to humans. It produces potent and rapid-acting venom and its sting causes severe localized and systemic effects that are potentially life-threatening ...
Brinkman, Diane L., Dash, Debasis, Jia, Xinying, Kumar, Dhirendra, Kvaskoff, David, Mulvenna, Jason, Potriquet, Jeremy   +6 more
core   +1 more source

Biologically active phenol and indole derivatives of terrestrial arthropods: electrophy­sio­logical and chemical characteristics

Біологічні студії, 2019
Toxins-antagonists of glutamatergic synapses were found in venoms of different terrestrial Arthrpopodae, both Insecta and Aranei. Chemical structures of some of them were described, and a majority of such substances are derivatives of phenol and indole ...
O. M. Klyuchko
doaj   +1 more source

Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from Three Loxosceles Spider Venoms. [PDF]

Int J Mol Sci, 2023
da Justa HC, Hernández González JE, Vuitika L, Mariutti RB, Magnago PAM, de Moraes FR, Senff-Ribeiro A, Gremski LH, Arni RK, Veiga SS.   +9 more
europepmc   +1 more source

Screening for Osteoporosis in Nonagenarians: A Scoping Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background As the United States population continues to age and advancements contribute to enhanced life expectancy, care for nonagenarians (adults aged 90 years and older) is as important as ever. A prominent concern within healthcare for the oldest old remains the occurrence of fragility fractures, and subsequent 1‐year mortality, making ...
Hannah A. Mosher, Hallie B. Remer, Kyra T. Berwitz, Giselle M. Hernandez, Marilyn Heng   +4 more
wiley   +1 more source

Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

Toxins, 2019
Voltage-gated sodium channels (NaVs) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit NaV channels have helped unravel the role of NaV channels in diseases, including chronic pain.
Yashad Dongol, Fernanda C. Cardoso, Richard J. Lewis   +2 more
doaj   +1 more source