Results 81 to 90 of about 6,046 (276)

Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

open access: yesFrontiers in Pharmacology, 2019
Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets.
Fernanda C. Cardoso, Richard J. Lewis
doaj   +1 more source

Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals [PDF]

open access: yes, 2013
The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Mourão, Caroline Barbosa Farias   +1 more
core   +3 more sources

Volumetric Comparison of Overall Brain and Neuropil Size Between Social and Non‐social Spiders: Exploring the Social Brain Hypothesis

open access: yesIntegrative Zoology, EarlyView.
Brain size may be influenced by the cognitive demands of sociality (social brain hypothesis). We used microCT to compare CNS and brain volumes in social versus solitary huntsman and crab spiders. Social huntsman spiders had larger arcuate and mushroom bodies, while social crab spiders had larger visual neuropils.
Vanessa Penna‐Gonçalves   +6 more
wiley   +1 more source

Toxins from scratch? Diverse, multimodal gene origins in the predatory robber fly Dasypogon diadema indicate a dynamic venom evolution in dipteran insects

open access: yes, 2019
Venoms and the toxins they contain represent molecular adaptations that have evolved on numerous occasions throughout the animal kingdom. However, the processes that shape venom protein evolution are poorly understood because of the scarcity of whole ...
Bokelmann, L.   +3 more
core   +1 more source

“A Place Where Freedom Means Something”: James Baldwin's Global Maroon Geographies

open access: yesAntipode, EarlyView.
Abstract Despite his vocal support for the Algerian revolution, Palestinian liberation, and the South African anti‐apartheid struggle, James Baldwin has continued to be regarded as a thinker whose work predominantly revolved around themes of civil rights, cross‐racial dialogue, and integration.
Ida Danewid
wiley   +1 more source

A complex network perspective on brain disease

open access: yesBiological Reviews, EarlyView.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

open access: yesToxins, 2017
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine,
David Wilson   +10 more
doaj   +1 more source

Spider bite: a current approach to management [PDF]

open access: yes, 2006
Although spider bite is common, most spider bites cause minor effects and do not require treatment. More significant effects result from redback and, less commonly, from funnel-web spider bites.
Isbister, Geoffrey K.
core   +2 more sources

A century of theories of balancing selection

open access: yesBiological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka   +10 more
wiley   +1 more source

Characterisation of novel insecticidal ion channel toxins from araneomorph and mygalomorph spider venoms [PDF]

open access: yes, 2011
University of Technology, Sydney. Faculty of Science.The high potency and selectivity of various peptide neurotoxins within spider venoms means these toxins are being considered as leads for the development of new environmentally-benign biopesticides ...
Chong, Y
core  

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