Abstract 1574 Structural insights into the dynamics of bat coronavirus spike glycoprotein
Toheeb Balogun +7 more
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SARS-CoV-2 infects olfactory neurons and basal stem cells and induces axonal degeneration through TRPV1 activation. [PDF]
Co VA +6 more
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Characterisation of Naturally Occurring MERS-CoV Spike Mutations and Their Impact on Fusion and Neutralisation. [PDF]
Dempsey R +10 more
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Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection. [PDF]
Zhang H +9 more
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In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV-2 using immunoinformatics. [PDF]
Zheng N, Xu Y.
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<b>Broadly cross-reactive mRNA COVID-19 vaccine encoding trimeric RBDs and NSP12 mitigates immune imprinting</b>. [PDF]
De Chiara A +18 more
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Endophytic fungi of Aegle marmelos as a source of novel antibacterials and anti-SARS-CoV agents. [PDF]
Goyal S +11 more
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A multiplexed, systems-based approach for prediction of antibody neutralization breadth for soluble human receptors. [PDF]
Wang Q +10 more
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Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions [PDF]
The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein. Unlike other enveloped viruses, CoVs bud and assemble at the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC).
Makoto Ujike, Fumihiro Taguchi
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Structural Bioinformatics to Unveil Weaknesses of Coronavirus Spike Glycoprotein Stability
2021Alternative strategies for developing antiviral drugs are needed, as vaccines could not be the final answer against the present SARS CoV-2 outbreak, due to the still existing ambiguities in the immunological response to the virus. Thus, SARS CoV-2 enzymes have been thoroughly investigated to develop their inhibitors as antiviral drugs. We have searched
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