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SARS-CoV-2 spike protein induces salivary gland dysfunction and immune infiltration in C57BL/6 mice [PDF]

Frontiers in Immunology
Salivary gland dysfunction and inflammation are common following SARS-CoV-2 infection. This study aimed to investigate the effects of SARS-CoV-2 spike and envelope proteins on glandular function in healthy C57BL/6 mice through direct intra-glandular ...
Fernanda Aragão Felix, Fernanda Aragão Felix, Yuqiao Jiang, Jing Zhou, Dongfang Li, Victoria Zhou, Sílvia Ferreira de Sousa, Kevin Matthew Byrd, Kevin Matthew Byrd, Qing Yu   +9 more
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Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics development

Current Research in Structural Biology, 2022
The comparison of 303,250 human SARS-CoV-2 spike protein sequences with the reference protein sequence Wuhan-Hu-1, showed ∼96.5% of the spike protein sequence has undergone the mutations till date, since outbreak of the COVID-19 pandemic disease that was
Kunchur Guruprasad
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The ORF8 Protein of SARS-CoV-2 Modulates the Spike Protein and Its Implications in Viral Transmission

Frontiers in Microbiology, 2022
COVID-19 is currently global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Accompanying the rapid spread of the error-prone RNA-based genome, several dominant SARS-CoV-2 variants have been genetically identified.
Jen-Mei Chou, Jen-Mei Chou, Jo-Ling Tsai, Jo-Ling Tsai, Jo-Ning Hung, Jo-Ning Hung, I-Hua Chen, I-Hua Chen, I-Hua Chen, Szu-Ting Chen, Szu-Ting Chen, Ming-Han Tsai, Ming-Han Tsai, Ming-Han Tsai   +13 more
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A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations

COVID, 2023
The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has sparked intense research on its spike protein, which is essential for viral entrance into host cells.
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha, Rene B. Khan, Hezekiel M. Kumalo   +4 more
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Different In Silico Approaches Using Heterocyclic Derivatives against the Binding between Different Lineages of SARS-CoV-2 and ACE2

Molecules, 2023
Over the last few years, the study of the SARS-CoV-2 spike protein and its mutations has become essential in understanding how it interacts with human host receptors.
Federica Sipala, Gianfranco Cavallaro, Giuseppe Forte, Cristina Satriano, Alessandro Giuffrida, Aurore Fraix, Angelo Spadaro, Salvatore Petralia, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Simone Ronsisvalle   +10 more
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FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

Journal of Lipid Research, 2022
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn   +13 more
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ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin

Cells, 2021
Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors to cause infection. The SARS-CoV-2 spike protein binds primarily to ACE2 on target cells and is then processed by membrane ...
Lynda J. Partridge, Lucy Urwin, Martin J. H. Nicklin, David C. James, Luke R. Green, Peter N. Monk   +5 more
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A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies

Frontiers in Virology, 2023
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine ...
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi   +24 more
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Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations

Frontiers in Chemistry, 2021
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). As of October 21, 2020, more than 41.4 million confirmed cases and 1.1 million deaths have been reported.
Sugunadevi Sakkiah, Wenjing Guo, Bohu Pan, Zuowei Ji, Gokhan Yavas, Marli Azevedo, Jessica Hawes, Tucker A. Patterson, Huixiao Hong   +8 more
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Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactions

AIMS Microbiology, 2020
Entry of SARS-CoV-2, etiological agent of COVID-19, in the host cell is driven by the interaction of its spike protein with human ACE2 receptor and a serine protease, TMPRSS2.
Mushtaq Hussain, Nusrat Jabeen, Anusha Amanullah, Ayesha Ashraf Baig, Basma Aziz, Sanya Shabbir, Fozia Raza, Nasir Uddin   +7 more
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