Results 11 to 20 of about 403,301 (348)

Carbohydrate Ligands for COVID-19 Spike Proteins [PDF]

Viruses, 2022
An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022 ...
Yung-Kuo Lee, Wen-Chiu Chang, Ekambaranellore Prakash, Yu-Ju Peng, Zhi-Jay Tu, Chun-Hung Lin, Pang-Hung Hsu, Chuan-Fa Chang   +7 more
doaj   +3 more sources

Fluorescent Glycan Fingerprinting of SARS2 Spike Proteins [PDF]

Scientific Reports, 2021
AbstractGlycosylation is the most common post-translational modification and has myriad biological functions. However, glycan analysis and research has always been a challenge. Here, we would like to present new techniques of glycan fingerprinting based on enzymatic fluorescent labeling and gel electrophoresis. The method is illustrated on SARS-2 spike
Zhengliang L Wu, James M Ertelt
openaire   +4 more sources

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACTSARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
openaire   +2 more sources

Enhancing epitope of PEDV spike protein

Frontiers in Microbiology, 2022
Porcine epidemic diarrhea virus (PEDV) is the causative agent of a highly contagious enteric disease of pigs characterized by diarrhea, vomiting, and severe dehydration. PEDV infects pigs of all ages, but neonatal pigs during the first week of life are highly susceptible; the mortality rates among newborn piglets may reach 80–100%.
Techit Thavorasak, Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung, Nitat Sookrung   +13 more
openaire   +3 more sources

Omicron Spike Protein is Vulnerable to Reduction

Journal of Molecular Biology, 2023
AbstractSARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible to reductive cleavage.
Zhong Yao, Betty Geng, Edyta Marcon, Shuye Pu, Hua Tang, John Merluza, Alexander Bello, Jamie Snider, Ping Lu, Heidi Wood, Igor Stagljar   +10 more
openaire   +2 more sources

SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function

International Journal of Molecular Sciences, 2023
Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets.
Boguslawa Luzak, Marcin Rozalski, Tomasz Przygodzki, Magdalena Boncler, Dagmara Wojkowska, Marcin Kosmalski, Cezary Watala   +6 more
openaire   +2 more sources

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity [PDF]

Nature Communications, 2020
Abstract SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S G614 ) with the original (S D614 ). We report here pseudoviruses carrying S
Zhang, Lizhou, Jackson, Cody B., Mou, Huihui, Ojha, Amrita, Peng, Haiyong, Quinlan, Brian D., Rangarajan, Erumbi S., Pan, Andi, Vanderheiden, Abigail, Suthar, Mehul S., Li, Wenhui, Izard, Tina, Rader, Christoph, Farzan, Michael, Choe, Hyeryun   +14 more
openaire   +3 more sources

Prefusion spike protein stabilization through computational mutagenesis [PDF]

Proteins: Structure, Function, and Bioinformatics, 2020
ABSTRACTA novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) has emerged as a human pathogen, causing global pandemic and resulting in over 400,000 deaths worldwide. The surface spike protein of SARS-CoV-2 mediates the process of coronavirus entry into human cells by binding angiotensin-converting enzyme 2 (ACE2).
Zhang, Dong Yan, Wang, Jian, Dokholyan, Nikolay V.   +2 more
openaire   +2 more sources

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Scientific Reports, 2021
The worse outcome of COVID-19 in people with diabetes mellitus could be related to the non-enzymatic glycation of human ACE2, leading to a more susceptible interaction with virus Spike protein.
Giovanni Sartore, Davide Bassani, Eugenio Ragazzi, Pietro Traldi, Annunziata Lapolla, Stefano Moro   +5 more
doaj   +1 more source

Mutations and Evolution of the SARS-CoV-2 Spike Protein

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +1 more source