Results 21 to 30 of about 980,274 (295)

Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin-labeling and PELDOR [PDF]

, 2012
Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt, Rouillon, Christophe, Schiemann, Olav, Sigurdsson, Snorri T, White, Malcolm F, Shelke, Sandip   +5 more
core   +1 more source

Site Selective and Efficient Spin Labeling of Proteins with a Maleimide-Functionalized Trityl Radical for Pulsed Dipolar EPR Spectroscopy

Molecules, 2019
Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS) in combination with site-directed spin labeling (SDSL) of proteins and oligonucleotides is a powerful tool in structural biology.
J. Jacques Jassoy, Caspar A. Heubach, Tobias Hett, Frédéric Bernhard, Florian R. Haege, Gregor Hagelueken, Olav Schiemann   +6 more
doaj   +1 more source

Base-specific spin-labeling of RNA for structure determination [PDF]

, 2007
To facilitate the measurement of intramolecular distances in solvated RNA systems, a combination of spin-labeling, electron paramagnetic resonance (EPR), and molecular dynamics (MD) simulation is presented. The fairly rigid spin label 2,2,5,5-tetramethyl-
Olav Schiemann, Mu, Yuguang, Prisner, Thomas F., Stock, G., Engels, J.W., Prisner, TF., Thomas F. Prisner, Engels, Joachim W. (Prof. Dr.), Stock, Gerhard, Piton, N., Schiemann, Olav, Gerhard Stock, Nelly Piton, Piton, Nelly, Mu, Y., Yuguang Mu, Joachim W. Engels   +16 more
core   +1 more source

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

Molecules, 2018
There is growing recognition regarding the role of intracellular amyloid beta (Aβ) in the Alzheimer’s disease process, which has been linked with aberrant signaling and the disruption of protein degradation mechanisms.
Silvia Hilt, Robin Altman, Tamás Kálai, Izumi Maezawa, Qizhi Gong, Sebastian Wachsmann-Hogiu, Lee-Way Jin, John C. Voss   +7 more
doaj   +1 more source

Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç [PDF]

, 2011
Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules.
Reginsson, Gunnar Widtfeldt, Olav Schiemann, Cekan, Pavol, Shelke, Sandip A., Adrian R. Ferré-D’Amaré, Gunnar W. Reginsson, Pavol Cekan, Edwards, Thomas E., Snorri Th. Sigurdsson, Schiemann, Olav, Sigurdsson, Snorri, Thomas E. Edwards, Ferre D'Amare, Adrian R., Sandip A. Shelke   +13 more
core   +1 more source

Synthesis of Spin-Labeled Ibuprofen and Its Interaction with Lipid Membranes

Molecules, 2022
Ibuprofen is a non-steroidal anti-inflammatory drug possessing analgesic and antipyretic activity. Electron paramagnetic resonance (EPR) spectroscopy could be applied to study its interaction with biological membranes and proteins if its spin-labeled ...
Denis S. Baranov, Anna S. Smorygina, Sergei A. Dzuba   +2 more
doaj   +1 more source

Tris[2,2,6,6-tetramethyl-8-(trimethylsilyl)benzo[1,2-d;4,5-d′]bis(1,3-dithiol)-4-yl]methanol diethyl ether monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compound, a triarylmethanol, C46H64OS12Si3 1, was synthesized via lithiation of tris-2,2,6,6-tetramethylbenzo[1,2-d;4,5-d′]bis[1,3]dithiol-4-yl-methanol, 2, and electrophilic quenching with trimethylsilyl chloride. The current crystal structure
Nico Fleck, Gregor Schnakenburg, Alexander C. Filippou, Olav Schiemann   +3 more
doaj   +1 more source

Background removal from rapid-scan EPR spectra of nitroxide-based spin labels by minimizing non-quadratic cost functions

Journal of Magnetic Resonance Open, 2023
Rapid-scan electron paramagnetic resonance spectroscopy is an emerging technique which substantially improves the signal-to-noise ratio and time resolution compared to conventional continuous-wave experiments.
Florian Johannsen, Malte Drescher
doaj   +1 more source

Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog

Molecules, 2000
Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5-tetramethylpyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.
Peter M. Gannett, Edward M. Johnson, Jeannine H. Powell   +2 more
doaj   +1 more source

Clusters of Spin Valve Sensors in 3D Magnetic Field of a Label

Sensors, 2021
Magnetic field sensors based on the giant magnetoresistance (GMR) effect have a number of practical current and future applications. We report on a modeling of the magnetoresistive response of moving spin-valve (SV) GMR sensors combined in certain ...
Georgy V. Babaytsev, Nikolay G. Chechenin, Irina O. Dzhun, Mikhail G. Kozin, Alexey V. Makunin, Irina L. Romashkina   +5 more
doaj   +1 more source