Results 21 to 30 of about 47,685 (161)

A Simple Method of Synthesis of 3-Carboxy-2,2,5,5-Tetraethylpyrrolidine-1-oxyl and Preparation of Reduction-Resistant Spin Labels and Probes of Pyrrolidine Series

Molecules, 2021
Stable free radicals are widely used as molecular probes and labels in various biophysical and biomedical research applications of magnetic resonance spectroscopy and imaging.
Sergey A. Dobrynin, Mikhail S. Usatov, Irina F. Zhurko, Denis A. Morozov, Yuliya F. Polienko, Yurii I. Glazachev, Dmitriy A. Parkhomenko, Mikhail A. Tyumentsev, Yuri V. Gatilov, Elena I. Chernyak, Elena G. Bagryanskaya, Igor A. Kirilyuk   +11 more
doaj   +1 more source

chiLife: An open-source Python package for in silico spin labeling and integrative protein modeling.

PLoS Computational Biology, 2023
Here we introduce chiLife, a Python package for site-directed spin label (SDSL) modeling for electron paramagnetic resonance (EPR) spectroscopy, in particular double electron-electron resonance (DEER).
Maxx H Tessmer, Stefan Stoll
doaj   +1 more source

Molecular Oxygen as a Probe Molecule in EPR Spin Labeling Studies of Membrane Structure and Dynamics

Oxygen, 2022
Molecular oxygen (O2) is the perfect probe molecule for membrane studies carried out using the saturation recovery EPR technique. O2 is a small, paramagnetic, hydrophobic enough molecule that easily partitions into a membrane’s different phases and ...
Witold K. Subczynski, Justyna Widomska, Marija Raguz, Marta Pasenkiewicz-Gierula   +3 more
doaj   +1 more source

Spin-labeled polyribonucleotides [PDF]

Nucleic Acids Research, 1980
Poly (U), poly (C) and poly (A) were spin labeled with N-(2,2,5,5-tetramethyl-3-carbonylpyrroline-1-oxyl)-imidazole. This spin label interacts selectively with 2' OH ribose groups of polynucleotides and does not modify the nucleic acid bases. The extent of spin labeling is not dependent upon the nature of the base and is entirely determined by rigidity
A I, Petrov, B I, Sukhorukov
openaire   +2 more sources

A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Scientific Reports, 2021
A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes.
Kevin Herr, Max Fleckenstein, Martin Brodrecht, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Torsten Gutmann, Michael Reggelin, Gerd Buntkowsky   +8 more
doaj   +1 more source

4-Dialkylamino-2,5-dihydroimidazol-1-oxyls with Functional Groups at the Position 2 and at the Exocyclic Nitrogen: The pH-Sensitive Spin Labels

Gels, 2021
Local acidity and electrostatic interactions are associated both with catalytic properties and the adsorption activity of various materials, and with the vital functions of biomolecules.
Dmitrii G. Trofimov, Yuri I. Glazachev, Artem A. Gorodetsky, Denis A. Komarov, Tatyana V. Rybalova, Igor A. Kirilyuk   +5 more
doaj   +1 more source

The binding isotherms for the interaction of 5-doxyl stearic acid with bovine and human albumin.

Journal of Lipid Research, 1978
Binding isotherms for the interaction of 5-doxyl stearic acid with bovine and human albumin are reported. The critical micelle concentration (CMC) and the limiting solubility of 5-doxyl stearic acid were determined using the electron spin resonance (ESR)-
S J Rehfeld, D J Eatough, W Z Plachy
doaj   +1 more source

Site Selective and Efficient Spin Labeling of Proteins with a Maleimide-Functionalized Trityl Radical for Pulsed Dipolar EPR Spectroscopy

Molecules, 2019
Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS) in combination with site-directed spin labeling (SDSL) of proteins and oligonucleotides is a powerful tool in structural biology.
J. Jacques Jassoy, Caspar A. Heubach, Tobias Hett, Frédéric Bernhard, Florian R. Haege, Gregor Hagelueken, Olav Schiemann   +6 more
doaj   +1 more source

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

Molecules, 2018
There is growing recognition regarding the role of intracellular amyloid beta (Aβ) in the Alzheimer’s disease process, which has been linked with aberrant signaling and the disruption of protein degradation mechanisms.
Silvia Hilt, Robin Altman, Tamás Kálai, Izumi Maezawa, Qizhi Gong, Sebastian Wachsmann-Hogiu, Lee-Way Jin, John C. Voss   +7 more
doaj   +1 more source

Synthesis of Spin-Labeled Ibuprofen and Its Interaction with Lipid Membranes

Molecules, 2022
Ibuprofen is a non-steroidal anti-inflammatory drug possessing analgesic and antipyretic activity. Electron paramagnetic resonance (EPR) spectroscopy could be applied to study its interaction with biological membranes and proteins if its spin-labeled ...
Denis S. Baranov, Anna S. Smorygina, Sergei A. Dzuba   +2 more
doaj   +1 more source