Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]
, 2017 In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R. +9 more
core +2 more sources
Journal of Neural Transplantation and Plasticity, 2016 Several studies have identified two types of sleep spindles: fast (13–15 Hz) centroparietal and slow (11–13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). Only few
M. Gorgoni +12 more
semanticscholar +1 more source
Deep-spindle: An automated sleep spindle detection system for analysis of infant sleep spindles
Computers in Biology and Medicine, 2022 Sleep spindles are an indicator of the development and integrity of the central nervous system in infants. Identifying sleep spindles manually in EEG is time-consuming and typically requires experienced experts. Automated detection of sleep spindles would greatly facilitate this analysis.
Lan Wei +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
General Cutting Load Model for Workload Simulation in Spindle Reliability Test
Machines, 2022 As the key functional component of the machine tool, the reliability test of the spindle is necessary to verify the reliability of the machine tool.
Lingda Kong +4 more
doaj +1 more source
A comparative study of using spindle motor power and eddy current for the detection of tool conditions in milling processes [PDF]
, 2015 This paper investigates the use of the power of the driving motor of a CNC spindle in comparison to two perpendicular eddy current sensors for the detection of tool wear in milling processes. Monitoring the power through the current profile is a low cost
Abbass, JK, Al-Habaibeh, A
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation [PDF]
Animal BioscienceObjective Oocyte quality is critical for the stable transmission of genetic information and affects early embryonic development. But the precise mechanisms governing oocyte meiotic progression remains largely unclear.
Qian Xu +8 more
doaj +1 more source
In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]
, 1990 To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ +3 more
core
Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes [PDF]
, 2013 We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation.
Abe, Hiroshi +9 more
core +1 more source