Results 61 to 70 of about 542,273 (348)
BMC Genetics, 2011 Background Metaphase cells have short spindles for efficient bi-orientation of chromosomes. The cohesin proteins hold sister chromatids together, creating Sister Chromatid Cohesion (SCC) that helps in the maintenance of short spindle lengths in metaphase.
Sanyal Kaustuv +4 more
doaj +1 more source
Structural Organization and Function of the Golgi Ribbon During Cell Division
Frontiers in Cell and Developmental Biology, 2022 The Golgi complex has a central role in the secretory traffic. In vertebrate cells it is generally organized in polarized stacks of cisternae that are laterally connected by membranous tubules, forming a structure known as Golgi ribbon.
Inmaculada Ayala, Antonino Colanzi
doaj +1 more source
Spindle configurations of skew lines
, 2004 We prove a conjecture of Crapo and Penne which characterizes isotopy classes of skew configurations with spindle-structure. We use this result in order to define an invariant, spindle-genus, for spindle-configurations.
Borobia +11 more
core +2 more sources
The spindle assembly checkpoint.
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed.
Pablo Lara-Gonzalez +2 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population
Frontiers in Neurology, 2019 Objective: Recent research suggests that sleep disorders or changes in sleep stages or EEG waveform precede over time the onset of the clinical signs of pathological cognitive impairment (e.g., Alzheimer's disease).
Jacques Taillard +18 more
doaj +1 more source
Analytical modeling for thermal errors of motorized spindle unit
, 2017 Modeling method investigation about spindle thermal errors is significant for spindle thermal optimization in design phase. To accurately analyze the thermal errors of motorized spindle unit, this paper assumes approximately that 1) spindle linear ...
Teng Liu +6 more
semanticscholar +1 more source
Meiotic spindle assembly and chromosome segregation in oocytes
Journal of Cell Biology, 2016 Centrosomes play a key role in organizing the microtubule spindle that separates chromosomes during mitosis. Bennabi et al. review how microtubule spindle formation and chromosomal segregation also occur in oocytes during cell division by meiosis despite
Isma Bennabi, M. Terret, M. Verlhac
semanticscholar +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source