Results 51 to 60 of about 403,042 (304)
TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]
, 2015 The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi +3 more
core +1 more source
Cancer, 1975 Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posterior neck almost exclusively ...
F M, Enzinger, D A, Harvey
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation [PDF]
Animal BioscienceObjective Oocyte quality is critical for the stable transmission of genetic information and affects early embryonic development. But the precise mechanisms governing oocyte meiotic progression remains largely unclear.
Qian Xu +8 more
doaj +1 more source
Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint" [PDF]
, 2007 Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the γ-tubulin ring complex (γ-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that γ-TuRC proteins play molecular roles in SAC activation. Because
Biggins, Sue +8 more
core +1 more source
Asymmetric spindle positioning [PDF]
Current Opinion in Cell Biology, 2006 When a spindle is positioned asymmetrically in a dividing cell, the resulting daughter cells are unequal in size. Asymmetric spindle positioning can be driven by regulated forces that can pull or push a spindle. The physical and molecular mechanisms that can position spindles asymmetrically have been studied in a number of systems, and some themes have
Erin K, McCarthy, Bob, Goldstein
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Recent advances in plant kinetochore research
Frontiers in Cell and Developmental BiologyFaithful chromosome segregation is crucial for cell division in eukaryotes, facilitated by the kinetochore, a multi-subunit protein complex that connects chromosomes to the spindle microtubules.
Elena Kozgunova, Elena Kozgunova
doaj +1 more source
Modal analysis of spindle of grinder machine based on ANSYS
上海师范大学学报. 自然科学版, 2015 The object of research is to a certain type grinding wheel spindle for which a 3D model of the spindle is established by SolidWorks software and ANSYS software is imported for model analysis.Natural frequency,vibration type and critical speed of the ...
HE Chaocong +4 more
doaj +1 more source
eLife, 2020 The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh +2 more
doaj +1 more source