Results 101 to 110 of about 959,308 (179)

CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging

open access: yesAging Cell, EarlyView.
This study investigates the mechanisms of oocyte aging in mice, identifying Calb1 and Rpl23 as key genes involved in calcium ion homeostasis and mitochondrial function. Knockdown of these genes led to mitochondrial dysfunction, meiotic defects, and spindle assembly abnormalities, while their overexpression partially rescued age‐related oocyte defects ...
Yingxue Han   +6 more
wiley   +1 more source

Isogenic Transplantation of Hybrid Artificial Pleural Tissue Consisting of Rat Cells and Polyglycolic Acid Nanofiber Sheet Induces Restoration of Mesothelial Defects in Rat Model

open access: yesArtificial Organs, EarlyView.
We have successfully constructed hybrid 3D tissue using mesothelial cells, fibronectin‐gelatin nanofilm‐coated fibroblasts, and collagen‐coated PGA nanofiber sheets to create artificial pleura, and achieved successful isogenic engraftment in a rat model of pleural defects. ABSTRACT Background Impairment of the visceral pleura following thoracic surgery
Kengo Tani   +5 more
wiley   +1 more source

YTHDC1 Modulates the Osteogenic Capacity of hPDLSCs via Wnt/β‐Catenin Signalling Pathway for the Treatment of Bone Defects in Osteoporosis Rats

open access: yesCell Proliferation, EarlyView.
In this study, human periodontal ligament stem cells (hPDLSCs) were successfully isolated and cultivated from the periodontal ligament tissues of healthy premolar teeth. Our in vivo experiments demonstrated that YTHDC1 augmented the osteogenic differentiation capacity of these cells via the Wnt/β‐catenin signalling pathway.
Dan Tan   +8 more
wiley   +1 more source

Accelerating Bone Healing With METTL3 Overexpressed Adipose‐Derived Stem Cells in Osteoporotic Rats

open access: yesCell Proliferation, EarlyView.
METTL3 promotes osteogenic differentiation of osteoporotic adipose‐derived stem cells and accelerates the repair of cranial defect areas in osteoporotic rats by activating the Wnt signalling pathway. ABSTRACT The treatment of postmenopausal osteoporosis (OP) presents a multifaceted challenge.
Hui Tang   +8 more
wiley   +1 more source

The role of electroencephalography in epilepsy research—From seizures to interictal activity and comorbidities

open access: yesEpilepsia, EarlyView.
Abstract Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both for basic and translational studies. Its contributions have advanced our understanding of epilepsy, shedding light on the pathophysiology and functional organization of epileptic networks, and the mechanisms underlying seizures.
Christos Panagiotis Lisgaras   +14 more
wiley   +1 more source

piRNA processing within non‐membrane structures is governed by constituent proteins and their functional motifs

open access: yesThe FEBS Journal, EarlyView.
The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley   +1 more source

Spindle assembly defects leading to the formation of a monopolar mitotic apparatus [PDF]

open access: bronze, 2008
Vanessa Tillement   +5 more
openalex   +1 more source

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