Results 171 to 180 of about 60,784 (278)

Silencing of spindle apparatus coiled-coil protein 1 suppressed the progression of hepatocellular carcinoma through farnesyltransferase-beta and increased drug sensitivity. [PDF]

Heliyon
Zhai Y, Wu F, Xu X, Zhao P, Xin L, Li M, Zong Y, Yang Z, Li Z, Wang L, Chen B.   +10 more
europepmc   +1 more source

From observation to understanding: A multi‐agent framework for smart microscopy

Journal of Microscopy, EarlyView.
Abstract Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision‐making and real‐time experimental control.
P. S. Kesavan, Pontus Nordenfelt
wiley   +1 more source

Differential Nap‐To‐Nap Stability of Sleep Spindles, Slow Waves, and their Temporal Coupling: An Exploratory Study

Journal of Sleep Research, EarlyView.
ABSTRACT Slow waves and sleep spindles characterise non‐rapid eye movement (NREM) sleep and support cognitive and plasticity‐related functions. While their stability across nights is well established, less is known about their consistency across daytime naps.
Damiana Bergamo, Antonino Visalli, Angie Baldassarri, Nicola Cellini   +3 more
wiley   +1 more source

The Potential of Ensemble‐Based Automated Sleep Staging on Single‐Channel EEG Signal From a Wearable Device

Journal of Sleep Research, EarlyView.
ABSTRACT Machine‐learning‐based sleep staging models have achieved expert‐level performance on standard polysomnographic (PSG) data. However, their application to EEG recorded by wearable devices remains limited by non‐conventional referencing montage and the lack of benchmarking against PSG.
Federico Salfi, Domenico Corigliano, Giulia Amicucci, Samantha Mombelli, Aurora D'Atri, John Axelsson, Michele Ferrara   +6 more
wiley   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species‐mediated mitogen‐activated protein kinase signaling activation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Atrial fibrillation (AF), the most common clinical arrhythmia, is driven by inflammatory activation and oxidative stress, though precise molecular links remain unclear. This study identifies the P2X7 receptor as a key upstream regulator orchestrating proarrhythmic atrial remodeling through reactive oxygen species (ROS)‐mediated mitogen ...
Lingnan Zhang, Yeran Zhu, Xinshun Gu
wiley   +1 more source

Circadian rhythm disruption declines oocyte quality for fertility via PTEN/AKT pathway. [PDF]

Protein Cell
Lu PS, Zhang KH, Wu SL, Ma RJ, Zou YJ, Ju JQ, Zhang HL, Wang Y, Sun SC.   +8 more
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Evaluation of Salt‐Tolerant Guar (Cyamopsis tetragonoloba L.) Genotypes Based on Physiological, Biochemical, and Yield‐Related Traits

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT The 15 guar genotypes were exposed to different concentrations of salt (0, 10, and 15 dS m−1 NaCl) in a factorial experiment (RCBD, r = 3) and different morpho‐physiological, physiological, growth, and yield characteristics were assessed. The lowest seed gum (21.11%), carbohydrate (23.59%), protein content (24.20%), fat (2.21%), fiber (9.38%),
WarqaaMuhammed ShariffAl‐Sheikh, Sahar A. A. Malik Al‐Saadi, Karzan Omer Qader, Heidar Meftahizade   +3 more
wiley   +1 more source